IBL/抗鼠RGMa兔IgG（冷冻）/JP28045/
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3392242852
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4000-520-616
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商品介绍
| Quantity/Tests | 100µg |
| Species/Antigen | rat |
| Host | Rabbit |
| Subclass/Clone | IgG |
| Type | Polyclonal |
| Purification | AffinityPurify |
| Label | N/A |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-RatRGMaRabbitIgG(Frozen)
RGMa(RepulsiveGuidanceMoleculea)isaGIP-anchoredprotein,about33kDa,anditisimplicatedinaxonalguidanceandneuraltubeclosureofembryonicretina.Ithasreportedasapotentinhibitorofaxonalregenerationintheadultcentralnervoussystem(CNS).ItisspeculatedthatRGMainhibitsneuriteoutgrowthbyactivatingtheRhoA-Rhokinasesignalingpathwayinvitro.While,ithasreportedthat,inaratSCI(spinalcordinjury)model,neuriteoutgrowthisenhancedbyadmiNISTrationofanti-RGMaantibodytolesionsite,resultingtheyareimprovedinmortorfunctionalrecovery.ThusfunctionanalysisofRGMaisattractingattentioninaresearchfieldofaxonalregenerationofCNS.ThisantibodydetectsratRGMaandcanbeusedforwesternblotting,immuno-precipitationandFACSanalysis.Anditisalsoreportedthatadministrationoftheantibodytocerebellargranulecellsof6-8days-oldrat,invitro,neutralizesRGMa-dependentinhibitionofneuriteoutgrowth.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.品牌介绍
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