IBL/Titin N片段ELISA/30124254/
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商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x1h,2x30min. |
| Standardrange | 46.00-3000pmol/L |
| Specimen/Volumes | 20µLurine |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:TitinN-FragmentELISA
Originalarticle#27900
Titin(connectin)isaproteinthatconsistsof34,350amino-acidsandspecificallyexpressesincross-striatedmuscle.Themolecularweightofhumantitinis3,816kDaanditisconsideredthelargestproteinamongallknownproteinsinalivingbody.Itisasarcomerestructuredproteinthatisaminimumunitofmyofibrillaryproteinandithasaroleasanelasticproteinforrecoveringthelengthofshortenedsarcomeresbyitscontraction.Ithasbeenknownthattitiniscleavedbymetabolicenzymessuchascalpainandmatrixmetalloproteaseifmusclesaredamaged.Infact,ithasbeenconfirmedthattitinisdramaticallycleavedinskeletalmusclesofmusculardystrophypatientsandvarioustitinfragmentsareconfirmedinbloodandurine.IthasbeenreportedthattheNfragment(26kDa)andtheCfragment(12kDa)areespeciallyincreasedinurineofmusculardystrophypatientsanditisalsosuggestedthatitcanbeacandidateasanon-invasivenessbioMarkerformonitoringstatusofmuscles.
ThisELISAkitcanmeasuretitinNfragmentinhumanandraturine.
Separatecontrolsetavailableonrequest
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Titin(connectin)isaproteinthatconsistsof34,350amino-acidsandspecificallyexpressesincross-striatedmuscle.Themolecularweightofhumantitinis3,816kDaanditisconsideredthelargestproteinamongallknownproteinsinalivingbody.Itisasarcomerestructuredproteinthatisaminimumunitofmyofibrillaryproteinandithasaroleasanelasticproteinforrecoveringthelengthofshortenedsarcomeresbyitscontraction.Ithasbeenknownthattitiniscleavedbymetabolicenzymessuchascalpainandmatrixmetalloproteaseifmusclesaredamaged.Infact,ithasbeenconfirmedthattitinisdramaticallycleavedinskeletalmusclesofmusculardystrophypatientsandvarioustitinfragmentsareconfirmedinbloodandurine.IthasbeenreportedthattheNfragment(26kDa)andtheCfragment(12kDa)areespeciallyincreasedinurineofmusculardystrophypatientsanditisalsosuggestedthatitcanbeacandidateasanon-invasivenessbioMarkerformonitoringstatusofmuscles.
ThisELISAkitcanmeasuretitinNfragmentinhumanandraturine.
Separatecontrolsetavailableonrequest
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