IBL/抗人RIG-I（CTD）兔IgG/JP28137/
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联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Quantity/Tests | 50µg |
| Species/Antigen | human,mouse |
| Host | rabbit |
| Subclass/Clone | IgG |
| Type | Polyclonal |
| Purification | withAntigenPeptide |
| Label | No |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-HumanRIG-I(CTD)RabbitIgG
Thisantibodywasraisedagainstthec-terminaldomainofhumanRIG-I.
RIG-I(retinoicacidinducIBLegene-I)isacytoplasmicviralsensor,thathasaRNAhelicasedomainanditisbelievedtorecognizevirus-deriveddouble-strandedRNA(dsRNA).ItisconsideredthatRIG-InormallyexistsasaninactiveforminthecytoplasmandturnstoanactiveformwhenitrecognizesdsRNAproducedasaby-productofviralreplication.ItisthoughtthattheactiveformofRIG-IexposesasignalingdomaincalledCARD(caspaserecruitmentdomain)whichisnormallyhiddenbysterichindrance.DownstreamsignalingthenisactivatedbymultimerizationandinteractionofCARDwithIPS-1expressedonmitochondria,eventuallyinducingtheactivationofinterferongene.Thus,RIG-Iisbelievedtoplayanimportantroleinviralinfection-inducedsignaling.
ThisantibodyrecognizesCTD(Cterminaldomain)ofRIG-IandisabletodetectRIG-IlocalizedinavSGs(antiviralstressgranules)thataregenesis-inducedinvirus-infectedcells.
DistributedbyIBLInternational
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.RIG-I(retinoicacidinducIBLegene-I)isacytoplasmicviralsensor,thathasaRNAhelicasedomainanditisbelievedtorecognizevirus-deriveddouble-strandedRNA(dsRNA).ItisconsideredthatRIG-InormallyexistsasaninactiveforminthecytoplasmandturnstoanactiveformwhenitrecognizesdsRNAproducedasaby-productofviralreplication.ItisthoughtthattheactiveformofRIG-IexposesasignalingdomaincalledCARD(caspaserecruitmentdomain)whichisnormallyhiddenbysterichindrance.DownstreamsignalingthenisactivatedbymultimerizationandinteractionofCARDwithIPS-1expressedonmitochondria,eventuallyinducingtheactivationofinterferongene.Thus,RIG-Iisbelievedtoplayanimportantroleinviralinfection-inducedsignaling.
ThisantibodyrecognizesCTD(Cterminaldomain)ofRIG-IandisabletodetectRIG-IlocalizedinavSGs(antiviralstressgranules)thataregenesis-inducedinvirus-infectedcells.
DistributedbyIBLInternational
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