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IBL/RF-Absorbent (additional reagent for the RE56xxx IgM ELISAs)/RE59059/
IBL/RF-Absorbent (additional reagent for the RE56xxx IgM ELISAs)/RE59059/
市场价：
¥0.00
美元价：
0.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 100tests(1mL) |
| Method | Reagent |
| Incubationtime | No |
| Standardrange | No |
| Specimen/Volumes | No |
| Substrate/isotope | No |
| RegulatoryStatus: | EU:CE |
Detailsfor:RF-Absorbent(additionalreagentfortheRE56xxxIgMELISAs)
Pleasenote:ThisproductisreplacedbyKIRF561!!!
Contains:Anti-humanIgGantibodies,protein-containingbuffer,stABIlizers.
RheumatoidfactorsareautoantibodiesmainlyoftheIgM-class.TheybindpreferablytoIgGantibodies.AmongtheunspecificIgGantibodiesinpatientsamplethereareoftenspecificIgGsdirectedagainstthecoatedantigen.TheRheumatoidfactorIgMantibodiesbindtothesespecificIgGantibodieswhicharedirectedagainsttheantigencoatedtotheplate.Thiscomplexisdetectedbytheantihumandetectionantibodies.Thisleadstofalsepositiveresultsinthepathogen-specificIgM-detection.
Anotherproblemthatoccursinthepathogen-specificIgM-detectionisthedisplacementofweakbindingpathogenspecificIgMantibodiesbystrongerbindingIgGantibodies.Thisleadstofalsenegativeresultsinthepathogen-specificIgM-detection.TheantihumanIgGantibodiesintheRF-AbsorbentbindtotheIgGantibodiesinthesample.AcrosslinkingtakesplacebetweentheIgGantibodies,theIgGantibodiesboundtotheRheumatoidfactorIgMantibodiesandtheantihumanIgGantibodies.Inthefollowingaprecipitationofthecomplextakesplace.
Thisprecipitationhastwogoals:
ThereforeIBLInternationalstronglyrecommendsthepretreatmentofpatientsamplesinthepathogen-specificIgM-detection.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Contains:Anti-humanIgGantibodies,protein-containingbuffer,stABIlizers.
SummaryandExplanation:
RheumatoidfactorsareautoantibodiesmainlyoftheIgM-class.TheybindpreferablytoIgGantibodies.AmongtheunspecificIgGantibodiesinpatientsamplethereareoftenspecificIgGsdirectedagainstthecoatedantigen.TheRheumatoidfactorIgMantibodiesbindtothesespecificIgGantibodieswhicharedirectedagainsttheantigencoatedtotheplate.Thiscomplexisdetectedbytheantihumandetectionantibodies.Thisleadstofalsepositiveresultsinthepathogen-specificIgM-detection.
Anotherproblemthatoccursinthepathogen-specificIgM-detectionisthedisplacementofweakbindingpathogenspecificIgMantibodiesbystrongerbindingIgGantibodies.Thisleadstofalsenegativeresultsinthepathogen-specificIgM-detection.TheantihumanIgGantibodiesintheRF-AbsorbentbindtotheIgGantibodiesinthesample.AcrosslinkingtakesplacebetweentheIgGantibodies,theIgGantibodiesboundtotheRheumatoidfactorIgMantibodiesandtheantihumanIgGantibodies.Inthefollowingaprecipitationofthecomplextakesplace.
Thisprecipitationhastwogoals:
- TheeliminationofspecificIgGantibodiesdirectedagainsttheantigencoatedtotheplate.(Avoidanceoffalsenegativeresult)
- TheeliminationoftheRheumatoidfactorIgMantibodieswhichareboundtothespecificIgGantibodiesinthesample.(Avoidanceoffalsepositiveresults)
ThereforeIBLInternationalstronglyrecommendsthepretreatmentofpatientsamplesinthepathogen-specificIgM-detection.
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