IBL/抗Dock6兔IgG亲和纯化/JP28111/
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商品介绍
| Quantity/Tests | 100µg |
| Species/Antigen | Syntheticpeptide |
| Host | Rabbit |
| Subclass/Clone | N/A |
| Type | N/A |
| Purification | Purifiedwithantigenpeptide |
| Label | N/A |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-Dock6RabbitIgGAffinityPurify
SmallGTPaseofRhofamilyisoneofsignalingfactorswhichcontrolalterationofcellularmorphology,celldivisionanddifferentiation,andplaysanimportantroleinregulationofgenerationandorganogenesisatanindividuallevel.Itsfunctionsarestrictlyregulatedanditsdysfunctioncausesmanydiseasessuchasimmunologicaldiseaseorneurodegenerativedisease.
Dedicatorofcytokinesis(Dock)6isaRhofamilysmallGTPaseactivatingfactor(orexchangefactor)activatingRac1andCdc42specificallyoftheRhofamilysmallGTPase,andiswidelyexpressedmolecule.ItisnotedthatDock6isanimportantfactorforproliferationanddifferentiationofneurocytessinceitismoreexpressedespeciallyinbrainandsensorynervetissues.Additionally,itisknownasaresponsIBLegeneforAdams-Oliversyndrome,inwhichdisordersofdeliveryandsexualdifferentiationareobserved,andwhichisassociatedwithmetabolicdisorderandintelligencedisorder.IthasbeenreportedthatmutationsinDock6causedeclineofitsfunctionandleadtoabnormalCytoskeletonorganization.
Thereareproteins,calledDock7andDock8,verysimilartoDock6inhumanbuttherearestillmanyunclearpointsabouttheirregulationsystems.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Dedicatorofcytokinesis(Dock)6isaRhofamilysmallGTPaseactivatingfactor(orexchangefactor)activatingRac1andCdc42specificallyoftheRhofamilysmallGTPase,andiswidelyexpressedmolecule.ItisnotedthatDock6isanimportantfactorforproliferationanddifferentiationofneurocytessinceitismoreexpressedespeciallyinbrainandsensorynervetissues.Additionally,itisknownasaresponsIBLegeneforAdams-Oliversyndrome,inwhichdisordersofdeliveryandsexualdifferentiationareobserved,andwhichisassociatedwithmetabolicdisorderandintelligencedisorder.IthasbeenreportedthatmutationsinDock6causedeclineofitsfunctionandleadtoabnormalCytoskeletonorganization.
Thereareproteins,calledDock7andDock8,verysimilartoDock6inhumanbuttherearestillmanyunclearpointsabouttheirregulationsystems.
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