
Kitsize | 12x8 |
Method | ELISA |
Incubationtime | 1x90min,1x30min,1x20min |
Standardrange | 0-2500ng/mL |
Specimen/Volumes | 15µLSerum,Plasma |
Substrate/isotope | TMB450nm |
RegulatoryStatus: | EU:CE |
ChromograninAisthemostimportantgeneralMarkerforthediagnosisandclinicalfollow-upofneuroendocrinetumors.Thismarkerisoftenelevatedinpatientswithfunctionallyactiveaswellasinactivetumors.UnlikeotherBIOLOGicalmarkers,chromograninAisrelativelystableandlargelycorrelateswiththetumormass.
IBLInternationalhassucceededinfurtheroptimizingthewell-establishedchromograninAELISA.ThenewchromograninAELISA(RE53071)correlatesperfectlywiththeoldversion(RE53971)andischaracterizedbythefollowingfeatures:
- Widermeasurementrange:upto2500ng/mL
- Nosampledilutionnecessary
- Improvedanalyticalsensitivity:1.4ng/mL
- Smallersamplevolume:15µL
- Nohookeffectupto1,000,000ng/mL
- Outstandingcorrelationwiththeoldassayversion(RE53971)
GeneralinformationonchromograninAELISA
ChromograninA(CgA)isa49kDaacidicglycoproteinconsistingof439aminoacidsencodedonchromosome14.Asamemberofthegraninfamily,chromograninAisstoredinandsecretedfromsecretorygranulesofendocrineandneuroendocrinecellsalongwiththeirhormonesandneurotransmitters.Ithasbeendemonstratedinanumberofnormalandneoplasticendocrinetissues.AnelevatedlevelofcirculatingchromograninAwasfoundtobeamarkeroftumorsofneuroendocrineorigin.ChromograninAcanbeusedforthefollowingindications: