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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > IBL/Chromogranin A ELISA (new version)/RE53071/
商品详细IBL/Chromogranin A ELISA (new version)/RE53071/
IBL/Chromogranin A ELISA (new version)/RE53071/
IBL/Chromogranin A ELISA (new version)/RE53071/
商品编号: RE53071
品牌: TECAN
市场价: ¥11140.00
美元价: 6684.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Kitsize12x8
MethodELISA
Incubationtime1x90min,1x30min,1x20min
Standardrange0-2500ng/mL
Specimen/Volumes15µLSerum,Plasma
Substrate/isotopeTMB450nm
RegulatoryStatus:EU:CE
Detailsfor: ChromograninAELISA(newversion)

ChromograninAisthemostimportantgeneralMarkerforthediagnosisandclinicalfollow-upofneuroendocrinetumors.Thismarkerisoftenelevatedinpatientswithfunctionallyactiveaswellasinactivetumors.UnlikeotherBIOLOGicalmarkers,chromograninAisrelativelystableandlargelycorrelateswiththetumormass.

IBLInternationalhassucceededinfurtheroptimizingthewell-establishedchromograninAELISA.ThenewchromograninAELISA(RE53071)correlatesperfectlywiththeoldversion(RE53971)andischaracterizedbythefollowingfeatures:

  • Widermeasurementrange:upto2500ng/mL
  • Nosampledilutionnecessary
  • Improvedanalyticalsensitivity:1.4ng/mL
  • Smallersamplevolume:15µL
  • Nohookeffectupto1,000,000ng/mL
  • Outstandingcorrelationwiththeoldassayversion(RE53971)

Figure:OutstandingcorrelationofthenewchromograninAELISA(RE53071)withtheoldversion(RE53971)

GeneralinformationonchromograninAELISA

ChromograninA(CgA)isa49kDaacidicglycoproteinconsistingof439aminoacidsencodedonchromosome14.Asamemberofthegraninfamily,chromograninAisstoredinandsecretedfromsecretorygranulesofendocrineandneuroendocrinecellsalongwiththeirhormonesandneurotransmitters.Ithasbeendemonstratedinanumberofnormalandneoplasticendocrinetissues.AnelevatedlevelofcirculatingchromograninAwasfoundtobeamarkeroftumorsofneuroendocrineorigin.

ChromograninAcanbeusedforthefollowingindications:

  1. Asaverysensitive(83%)andhighlyspecific(96%)markerintheevaluationofaconfirmedorsUSPectedpheochromocytoma.DrugsthatarecommonlyusedinthediagnosisandtreatmentofpheochromocytomahaveanegligibleeffectontheplasmachromograninAlevels,whichisaconsiderableadvantageofchromograninAovercatecholaminesforthemeasurementpurposes.
  2. Verificationoftumororigin.HighchromograninAlevelsindicatethatthetumorisofneuroendocrineorigin.
  3. Detectionofendocrinetumorsthatsecretenon-tissue-specifichormones,suchasC-cellcancernegativeforcalcitoninandpositiveforchromogranin;nullcelladenoma,pancreaticbeta-celltumorsandparathyroidtumors.

ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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