InositoIgG/IgMELISAisasolidphaseenzymeimmunoassaywithhighlypurifiedhumanphosphatidyl-inositolplusnativehumanß2-glycoproteinIforthequantitativedetectionofIgGandIgMantibodiesagainstphosphatidyl-inositolinhumanserum.Theseantibodiesrecognizespecificepitopesonacomplexcomposedoutofphosphatidyl-inositolandß2-glycoproteinIwhichareonlypresentwhenthesetwomoleculesinteract.Theassayisanaidinthediagnosisandriskestimationofthrombosisinpatientswithsystemiclupuserythematosus.Antibodiesagainstphosphatidyl-inositol,anphospholipidderivedfromglycerol,belongtothegroupofanti-phospholipidantibodiesspecificforphospholipidssuchascardiolipin,phosphatidyl-serine,-ethanolamin,-choline,sphingomyelinandphosphatidicacid.PhospholipidsarecomponentsofBIOLOGicalmembranes.Anti-phospholipidantibodiesarefrequentlyfoundinseraofpatientswithsystemiclupuserythematosus(SLE)andrelateddiseases.Theoccurrenceofanti-phospholipidantibodiesinpatientswithSLEandrelateddiseasesistypicalforasecondaryanti-phospholipidsyndrome(APS).Incontrast,antiphospholipidantibodiesinpatientswithnootherautoimmunediseasescharacterizetheprimaryAPS.Manystudieshaveshownacorrelationbetweentheseautoantibodiesandanenhancedincidenceofthrombosis,thrombocytopeniaandhABItualabortions(asaconsequenceofplacentalinfarction).Theexactmechanismsbywhichpathogenicanti-phospholipidantibodiesinducethrombosisisnotyetrevealedfully.