IBL/CENP-B-Ab ELISA/RE75261/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 3x30min |
| Standardrange | 0-60U/mL,cut-off4U/mL |
| Specimen/Volumes | 5µLserum |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | EU:CE |
Detailsfor:CENP-B-AbELISA
EnzymeimmunoassayforthequalitativeandquantitativedeterminationofIgGantibodiesagainstCENP-Binhumanserum.Autoantibodiesdirectedatantigensofthechromosomecentromere(ACA)areconsideredasdiagnosticMarkeroftheso-calledCRESTsyndrome.Thisisthelimitedcutaneousvariantofprogressivesystemicsclerosis(PSS,scleroderma),achronic-inflammatory,autoimmunemediateddisorderoftheconnectivetissue.Itsmainmanifestationisathickeningandhardeningoftheskin,butinnerorganscanbeaffectedaswell.Apparently,ACAprognosticateamilder,moreprotractedcourseofthedisease,mostlywithoutpulmonary,cardiacorrenalmanifestation.Incontrast,Scl-70autoantibodiesasspecificmarkerofPSSindicateitsseverecourse(diffusescleroderma).PatientswiththeCRESTsyndromrarelycarryScl-70autoantibodies.CentromereproteinB(CENP-B)isconsideredasthedominantcentromereantigen.
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