IBL/sRANKL总ELISA/BV51131/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 96 |
| Method | ELISA |
| Incubationtime | 1x20h;1x2h;1x1h;1x25min |
| Standardrange | 0 |
| Specimen/Volumes | 50µL |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:sRANKLtotalELISA
RANKLisanabbreviationforreceptorofNF-kappaBligandandisalsoknownasosteoprotegerinligandandispartoftheTNFsuperfamilyofproteins.
Itisexpressedin3isoforms.
Thesolubleformisprocessedbyproteolyticcleavageofthemembrane-boundisoforms.Thesemembrane-boundisoformsseemtobethehomeostaticforms,whileproductionofthesolubleformseemstoindicatepathologicalconditions.
RANKL,RANKandosteoprotegerin(OPG)arethekeymolecularregulatorsforboneremodelling.RANKLstimulatesthematurationofosteoclastsandisessentialfortheirsurvival.Thus,anincreaseinRANKLexpressionleadstoboneresorptionandbonelossandimbalancesintheRANKL/OPGsystemarerelatedtothepathogenesisofpostmenopausalosteoporosis,hypercalcemia,Paget"sdisease,rheumatoidarthritis,benignaswellasmalignantbonetumorsandbonemetastases.
InanimalmodelsitwasshownthatrestoringtheRANKL/OPGbalancewillleadtoareductionoftheseverityofthesedisorders.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Itisexpressedin3isoforms.
Thesolubleformisprocessedbyproteolyticcleavageofthemembrane-boundisoforms.Thesemembrane-boundisoformsseemtobethehomeostaticforms,whileproductionofthesolubleformseemstoindicatepathologicalconditions.
RANKL,RANKandosteoprotegerin(OPG)arethekeymolecularregulatorsforboneremodelling.RANKLstimulatesthematurationofosteoclastsandisessentialfortheirsurvival.Thus,anincreaseinRANKLexpressionleadstoboneresorptionandbonelossandimbalancesintheRANKL/OPGsystemarerelatedtothepathogenesisofpostmenopausalosteoporosis,hypercalcemia,Paget"sdisease,rheumatoidarthritis,benignaswellasmalignantbonetumorsandbonemetastases.
InanimalmodelsitwasshownthatrestoringtheRANKL/OPGbalancewillleadtoareductionoftheseverityofthesedisorders.
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