IntercellularAdhesionMolecule-1(ICAM-1)isamemberoftheimmunoglobulinsupergenefamilyandfunctionsasaligandfortheLymphocyteFunction-AssociatedAntigen-1(LFA-1),analpha-betacomplexthatisamemberoftheleukocyteintegrinfamilyofcell-cellandcell-matrixreceptors.ThisfamilyconsistsoftheleukocyteadhesionglycoproteinsLFA-1whichmediateslymphocyteadhesion,Mac-1whichmediatesgranulocyteadhesionandp150,95.ICAM-1isasingle-chainglycoproteinwithapolypeptidecoreof55kD.TheroleofICAM-1asadiseaseMarkerhasbeendemonstratedforanumberofdifferentindicationsandpathologicalsituations.
ICAM-1upregulationisdetectedinallergicdisorders(airwayinflammation,allergiccontactdermatitis),cancer(GI-cancer,lymphoidmalignancies,malignantmelanoma),infectiousdisease(HIV-1,malariatropica,hepatitisB),transplantrejection(transplantedheart,transplantedkidney,livertransplants),diabetesmellitus,myocardialinfarction,glomerulonephritis,inflammatoryprocesswithinthecentralnervoussystem,rheumatoidarthritisandpsoriasis.

Synonyms:Intercellularadhesionmolecule1,Majorgrouprhinovirusreceptor,CDantigenCD54