IBL/IL-21（IL-21）ELISA/BE53211/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x3h,1x1h,1x10min. |
| Standardrange | 78-5000pg/ml |
| Specimen/Volumes | 50µlserum,plasma,cellculturesupernatantetal. |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Interleukin-21(IL-21)ELISA
ThehumanIL-21ELISAisanenzyme-linkedimmunosorbentassayforthequantitativedetectionofhumanIL-21.ThehumanIL-21ELISAisforresearchuseonly.Notfordiagnosticortherapeuticprocedures.
Interleukin-21isamemberofthetype-Icytokinefamily.Structurally,IL-21showshomologytoIL-2,IL-4,andIL-15proteins.IL-21sharesthecommongamma-chainwiththesethreecytokines,but,inaddition,bindstoauniqueIL-21Ralphachain,andactivatestheJAK/STATpathway.
IL-21haspleiotropicactions,fromaugmentingtheproliferationofTcellsanddrivingthedifferentiationofBcellsintomemorycellsandterminallydifferentiatedplasmacellstoaugmentingtheactivityofnaturalkillercells.IL-21ismainlyproducedbyactivatedT-cells,buttargetsabroadrangeoflymphoidandmyeloidcellsoftheimmunesystemandthereforeisabletoregulateinnateandacquiredimmuneresponses.IL-21haspathologicfunctioninimmune-inflammatorydiseases.DatasuggesttheexistenceofapositiveautocrineloopthatcouldhelptoamplifyandstABIlizeIL-21-driven,Tcell-mediatedresponses.Moreover,ithasantitumouractivityandmayhavearoleinthedevelopmentofautoimmunity.IL-21mayhavetherapeuticpotentialsasanantitumoragentintheclinic.
Synonyms:Za11,CytokineCX2
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Interleukin-21isamemberofthetype-Icytokinefamily.Structurally,IL-21showshomologytoIL-2,IL-4,andIL-15proteins.IL-21sharesthecommongamma-chainwiththesethreecytokines,but,inaddition,bindstoauniqueIL-21Ralphachain,andactivatestheJAK/STATpathway.
IL-21haspleiotropicactions,fromaugmentingtheproliferationofTcellsanddrivingthedifferentiationofBcellsintomemorycellsandterminallydifferentiatedplasmacellstoaugmentingtheactivityofnaturalkillercells.IL-21ismainlyproducedbyactivatedT-cells,buttargetsabroadrangeoflymphoidandmyeloidcellsoftheimmunesystemandthereforeisabletoregulateinnateandacquiredimmuneresponses.IL-21haspathologicfunctioninimmune-inflammatorydiseases.DatasuggesttheexistenceofapositiveautocrineloopthatcouldhelptoamplifyandstABIlizeIL-21-driven,Tcell-mediatedresponses.Moreover,ithasantitumouractivityandmayhavearoleinthedevelopmentofautoimmunity.IL-21mayhavetherapeuticpotentialsasanantitumoragentintheclinic.
Synonyms:Za11,CytokineCX2
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