IBL/IL-17AF（IL-17AF）ELISA/BE53181/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x1h,1x30min. |
| Standardrange | 31.3-2000pg/mL |
| Specimen/Volumes | 50µlserum,plasma,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Interleukin-17AF(IL-17AF)ELISA
Interleukins17F(IL-17F)and17A(IL-17A)arecloselyrelatedmembersoftheIL-17cytokinefamily,sharingabout50%aminoacididentity.StudiesinthemousehaveidentifiedTh17cellsasadistinctCD4+TcelllineagethatisdefinedbytheproductionofIL-17FandIL-17A.IL-6andtransforminggrowthfactor-βarerequiredforthedifferentiationofnaïveCD4+TcellstoTh17cells,whicharemaintainedinthepresenceofIL-23andIL-1β.Conversely,IL-4andinterferon-γcaninhibitthedevelopmentofTh17cells.Th17cellshavebeenimplicatedinthepathologyofmouseautoimmunediseasemodels.ExpressionofIL-17FandIL-17Ahasbeendetectedinactivatedhumanperipheralbloodlymphocytes.IthasbeenshownthatthecytokinesareexpressedinactivatedhumanCD4+Tcells.ExpressionofIL-17FandIL-17Ahasalsobeenobservedintissuesamplesfromvariousautoimmunediseasessuchasrheumatoidarthritis,multiplesclerosis,psoriasis,inflammatoryboweldisease,andasthma.ThecrystalstructureofIL-17Fhasbeensolvedandshowsthattheproteinformsadisulfide-linkeddimericglycoprotein.IL-17Aisalsoadisulfide-linkedhomodimericglycoprotein.TheIL-17Fhomodimerincludesaclassicalcysteineknotmotif,whichisfoundintheTGF-β,bonemorphogeneticprotein,andnervegrowthfactorsuperfamilies.OnedifferenceinthecysteineknotmotifofIL-17Fcomparedwiththeotherknowncysteineknotproteinfamiliesisthatitonlyutilizesfourcysteinesinsteadoftheclassicalsixcysteinestoformtheknot.IL-17FandIL-17AhavebeenshowntoformBIOLOGicallyactiveIL-17F/IL-17Aheterodimers,inadditiontotheIL-17FandIL-17Ahomodimers.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.品牌介绍
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