IBL/IL-12/IL-23 p40 ELISA/BE53221/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x3h,1x1h,1x10min. |
| Standardrange | 31.3-2000pg/mL |
| Specimen/Volumes | 50µLserum,plasma,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:IL-12/IL-23p40ELISA
IL-23andIL-12areheterodimericcytokineswhichsharethep40subunit,buthaveuniquesecondsubunits,IL-23p19andIL-12p35.IL-12p70isaheterodimercomposedofa35-kDasubunit(IL-12p35)andthe40-kDasubunit(IL-12p40)thatbindstheIL-12receptor.Thep40subunitissecretedinexcessofIL-12p35andcanalsoassociatewithp19(IL-23P19orIL-23A)toformIL-23.Thep19subunitsharessequencesimilaritywithIL-6subfamilymembersandisdistantlyrelatedtothep35subunitofIL-12.ItshowsnoBIOLOGicalactivitybyitselfandcombineswiththep40subunitofIL-12toformabiologicallyactive,compositecytokine,IL-23.IL-23signalsthroughtheIL-23receptorandhasfunctionsthatoverlapwithandaredistinctfromthoseofIL-12.UnlikeIL-12,IL-23hasnoeffectonnaiveTcellsbutselectivelyactivatesmemoryTcellstosecreteIFN-andIL-17.IL-23ismorepotentthanIL-12ininducinglong-lastingT-cellresponsestoviralantigensandcaninducetumor-directedcytotoxicT-cellresponses.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.品牌介绍
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