IBL/半乳糖缺乏IgA1 ELISA/3011694/
市场价：
¥0.00
美元价：
0.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x1h,2x30min. |
| Standardrange | 1.56-100ng/mL |
| Specimen/Volumes | 5µLserum,plasma |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:GalactoseDeficientIgA1ELISA
"Originalarticle#27600
Galactose-deficientIgA1(Gd-IgA1)attractsalotofattentionasacriticaleffectormoleculeinthepathogenesisandprogressionofIgAnephropathy(IgAN)inrecentstudies.IthasbeensuggestedthatseveralO-linkglycan-modifiedregionsexistintheheavychainhingeregionofhumanIgA1moleculeandthatGd-IgA1circulatesinthebloodofpatientswithpathologicalconditionofIgAN.Themeasuringsystemusingsnail(helixaspersa;HAA)lectin,thatisextractedfromsnails,hasbeenusedinnumerousstudiesinthepastanditwasrevealedthatserumlevelsofGd-IgA1inpatientswithIgANaresignificantlyelevatedcomparedtothelevelsofhealthysubjectsorpatientswithrenaldiseasesotherthanIgAN.Thus,theimportanceandpurposeofmeasuringserumGd-IgA1levelhavebeengraduallyrecognizedfromsuchstudies.
However,sincethemeasuringsystemusingHAAlectinisnotsuitableformeasuringmultipleandmassivesamplesinlargescalestudiesduetoitsinstABIlityofglycan-recognizingactivity,thedevelopmentofanalternativemeasuringsystemthatcanquantitativelymeasurehumanGd-IgA1inserumwithstableandreliabledatahasbeenconsideredasanessentialandurgentmatter.ThisIBLELISAkitusingamonoclonalantibodythatspecificallyrecognizesthegalactose-deficienthingesequenceofhumanGd-IgA1isanon-lectin-dependentmeasuringsystemthatcanquantitativelymeasureGd-IgA1inhumanserum,whichisalsosuitableforlargescalestudiesbecauseofitsstability."
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Galactose-deficientIgA1(Gd-IgA1)attractsalotofattentionasacriticaleffectormoleculeinthepathogenesisandprogressionofIgAnephropathy(IgAN)inrecentstudies.IthasbeensuggestedthatseveralO-linkglycan-modifiedregionsexistintheheavychainhingeregionofhumanIgA1moleculeandthatGd-IgA1circulatesinthebloodofpatientswithpathologicalconditionofIgAN.Themeasuringsystemusingsnail(helixaspersa;HAA)lectin,thatisextractedfromsnails,hasbeenusedinnumerousstudiesinthepastanditwasrevealedthatserumlevelsofGd-IgA1inpatientswithIgANaresignificantlyelevatedcomparedtothelevelsofhealthysubjectsorpatientswithrenaldiseasesotherthanIgAN.Thus,theimportanceandpurposeofmeasuringserumGd-IgA1levelhavebeengraduallyrecognizedfromsuchstudies.
However,sincethemeasuringsystemusingHAAlectinisnotsuitableformeasuringmultipleandmassivesamplesinlargescalestudiesduetoitsinstABIlityofglycan-recognizingactivity,thedevelopmentofanalternativemeasuringsystemthatcanquantitativelymeasurehumanGd-IgA1inserumwithstableandreliabledatahasbeenconsideredasanessentialandurgentmatter.ThisIBLELISAkitusingamonoclonalantibodythatspecificallyrecognizesthegalactose-deficienthingesequenceofhumanGd-IgA1isanon-lectin-dependentmeasuringsystemthatcanquantitativelymeasureGd-IgA1inhumanserum,whichisalsosuitableforlargescalestudiesbecauseofitsstability."
品牌介绍
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