IBL/抗人Gd-IgA1（KM55）大鼠IgG/30123640/
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3392242852
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4000-520-616
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商品介绍
| Quantity/Tests | 100µg |
| Species/Antigen | HumanIgA1hingeregionpeptidewithGalNAc |
| Host | Rat |
| Subclass/Clone | IgG |
| Type | Polyclonal |
| Purification | ProteinA |
| Label | No |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-humanGd-IgA1(KM55)RatIgG
"Originalarticle#10777
Galactose-deficientIgA1(Gd-IgA1)attractsalotofattentionsasacriticaleffectormoleculeinthepathogenesisandprogressionofIgAnephropathy(IgAN)inrecentstudies.IthasbeensuggestedthatseveralO-linkglycansmodifiedregionsexistintheheavychainhingeregionofhumanIgA1moleculeandGd-IgA1circulatesinthebloodstreamofpatientswiththepathologicalconditionofIgAN.ThedepositionofGd-IgA1inglomeruliisconsideredtobeinvolvedinIgAN(Multi-hitHypothesisofGd-IgA1).Themeasuringsystemusingsnail(Helixaspersa;HAA)lectinthatisextractedfromsnailandGd-IgA1ELISA(Code:27600Gd-IgA1(Galactose-deficientIgA1)AssayKitusingthisantibody(KM55)havebeenusedinnumerousstudiesandithasbeensuggestedthatserumlevelsofGd-IgA1inpatientswithIgANissignificantlyelevatedcomparedtothelevelsofhealthysubjectsorpatientswithrenaldiseaseotherthanIgANinsuchstudies.Inaddition,thisantibody(KM55)candetectGd-IgA1intissuebyIHCtechniquedifferentlyfromthefeatureofHAAlectinandithasbeenrevealedthatGd-IgA1specicillayexistsinglomeruliofthepatientsofIgANfromthestudiesusingthisantibody.IthasbeenexpectedthatclinicalsignificanceofGd-IgA1wilberevealedbyfurtherstudiesusingthisantibody."
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Galactose-deficientIgA1(Gd-IgA1)attractsalotofattentionsasacriticaleffectormoleculeinthepathogenesisandprogressionofIgAnephropathy(IgAN)inrecentstudies.IthasbeensuggestedthatseveralO-linkglycansmodifiedregionsexistintheheavychainhingeregionofhumanIgA1moleculeandGd-IgA1circulatesinthebloodstreamofpatientswiththepathologicalconditionofIgAN.ThedepositionofGd-IgA1inglomeruliisconsideredtobeinvolvedinIgAN(Multi-hitHypothesisofGd-IgA1).Themeasuringsystemusingsnail(Helixaspersa;HAA)lectinthatisextractedfromsnailandGd-IgA1ELISA(Code:27600Gd-IgA1(Galactose-deficientIgA1)AssayKitusingthisantibody(KM55)havebeenusedinnumerousstudiesandithasbeensuggestedthatserumlevelsofGd-IgA1inpatientswithIgANissignificantlyelevatedcomparedtothelevelsofhealthysubjectsorpatientswithrenaldiseaseotherthanIgANinsuchstudies.Inaddition,thisantibody(KM55)candetectGd-IgA1intissuebyIHCtechniquedifferentlyfromthefeatureofHAAlectinandithasbeenrevealedthatGd-IgA1specicillayexistsinglomeruliofthepatientsofIgANfromthestudiesusingthisantibody.IthasbeenexpectedthatclinicalsignificanceofGd-IgA1wilberevealedbyfurtherstudiesusingthisantibody."
品牌介绍
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