IBL/抗人CD109（11H3）小鼠IgG/JP10381/
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4000-520-616
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商品介绍
| Quantity/Tests | 100µg |
| Species/Antigen | RecombinantproteinofC-terminalportionofhumanCD109 |
| Host | Mouse |
| Subclass/Clone | IgG1/11H3 |
| Type | Monoclonal |
| Purification | ProteinA |
| Label | No |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-humanCD109(11H3)MouseIgG
CD109isaglycosyl-phosphatidyl-inositol(GPI)-anchoredglycoproteinabout180-190kDasize.ItisshownthatCD109isexpressedinvascularendothelialcells,someepithelialcells,activatedT-cellsandplatelets,andsubsetofCD34+megakaryocyticleukemiacells.TheCD109moleculesarestronglyexpressedinKG1acells,whileCD34+CD109+cellsinfetalbonemarrowincludealmostallmyelocytic,erythroblasticandmegakaryocyticprecursorcells.Forthisreason,CD109isconsideredtobeaMarkerofmegakaryocytichematopoiesisinearlystage.AndCD109isconsidereddifferentfromexistingactivationmarkersofleukocytesandplatelets,becauseofitsstructureandSEROlogicalfeatures.ByreportsofTakahashietal.,CD109issignificantlyoverexpressedinsquamouscellcarcinomassuchaslungcarcinoma,esophagealcarcinomaanduterinecervicalcarcinoma.Thus,itisattractingattentionforstudyingsquamouscellcarcinomas.Additionally,arecentstudysuggeststhatCD109isinvolvedintheregulationoftransforminggrowthfactor(TGF)-βsignalinginsomecancercellsandkeratinocytes.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.品牌介绍
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