IBL/抗人β淀粉样蛋白(38-42)(44A3)小鼠IgG/30135335/
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美元价:
0.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Quantity/Tests | 50µg |
Species/Antigen | SyntheticpeptideofhumanAmyloid-beta(38-42)(GVVIA) |
Host | Mouse |
Subclass/Clone | IgG2b |
Type | Monoclonal |
Purification | ProteinA |
Label | No |
RegulatoryStatus: | Forresearchuseonly |
Detailsfor: Anti-HumanAmyloid-beta(38-42)(44A3)MouseIgG
"Originalarticle#11115
Alzheimer"sdisease(AD)ischaracterizedbythepresenceofextracellularplaquesandintracellularneurofibrillarytangles(NFTs)inthebrain.Themajorproteincomponentoftheseplaquesisbetaamyloid(Aβ)peptide,a40to43aminoacidpeptidecleavedfromamyloidprecursorproteinbyβ-secretaseandγ-secretase.IncreasedreleaseofAβ42orAβ43,bothofwhichexibitagreatertendencytoaggregatethanAβ40,occursinindividualsexpressingcertaingeneticmutations,ApoEallelesormayinvolveotherundiscoveredfactors.ManyresearcherstheorizethatitisthisincreasedreleaseofAβ42/Aβ43whichleadstotheabnormaldepositionofAβandtheassociatedneurotoxicityinthebrainsofaffectedindividuals."
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Alzheimer"sdisease(AD)ischaracterizedbythepresenceofextracellularplaquesandintracellularneurofibrillarytangles(NFTs)inthebrain.Themajorproteincomponentoftheseplaquesisbetaamyloid(Aβ)peptide,a40to43aminoacidpeptidecleavedfromamyloidprecursorproteinbyβ-secretaseandγ-secretase.IncreasedreleaseofAβ42orAβ43,bothofwhichexibitagreatertendencytoaggregatethanAβ40,occursinindividualsexpressingcertaingeneticmutations,ApoEallelesormayinvolveotherundiscoveredfactors.ManyresearcherstheorizethatitisthisincreasedreleaseofAβ42/Aβ43whichleadstotheabnormaldepositionofAβandtheassociatedneurotoxicityinthebrainsofaffectedindividuals."
品牌介绍
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