| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x1h,1x30min,1x15min |
| Standardrange | cutoffindex |
| Specimen/Volumes | 10µlserum,plasma |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | EU:CE |
Ascaridaearebignematodes.Themaleindividualsareupto25cm,thefemaleonesareupto40cmlong.AscarislumbricoidesisamongtheAscaridaethespecieswiththehighestimportanceforhumanmedicine,becauseitistheonlyonewithhumansasmainhost.Thesexuallymatureroundwormlivesinthesmallintestine.Thefemalesproduceupto200000eggsdaily,whichattaintotheenvironmentbyfaeces.Infectiouslarvaedevelopinsidetheeggsandafteroralingestiontheyhatchintheupperpartofthesmallintestine.Theypenetratethewalloftheintestineandgetintothevenousbloodwithwhichtheygetintoliverandlung,wheretheyleavethevesselsandskinintheaveoles.Thelarvaemigrateintothetracheaandthroughthepharynxafterswallowingbacktothesmallintestinewherethematurationtotheadultwormtakesplace.Ca.10-12weeksafterinfestationtheroundwormswillbeexcretedwithfaeces.Theadultwormlivesforaround18months.AscarislumbricoidesisoneofthemostabundantexciterofInfectiousDiseasesworldwide.MainendemicareasareEasternAsia,AfricaandMiddleandSouthAmerica.Childrenaremoreoftenaffectedthanadults.TheinfestationleadstoAscariasismostlywithlatentprogression.Themigratinglarvaecanleadtoinflammatory,eosinophileinfiltrationofthelungandcausecough,dyspnoeaandlightfever.Conglomeratesofthewormscancauseintestinalblockage.Ifthewormsmigrateintogall,pancreasorstomachthecorrespondingclinicalsymptomsresult.Thepresenceofaninfectionmaybeidentifiedby:
- Microscopy:Detectionofeggsinfaeces
- SEROlogy:DetectionofantibodiesbyELISA
