IBL/MMP-9（基质金属蛋白酶-9）ELISA/BE59491/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
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3392242852
电话号码：
4000-520-616
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info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h;1x1h;1x10min. |
| Standardrange | 0.23-15ng/mL |
| Specimen/Volumes | 10µLserum,plasma,cellculturesupernatantetal. |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | EU:CE |
Detailsfor:MMP-9(MatrixMetalloprotease-9)ELISA
MMP-9isaZn+2dependentendopeptidase,synthesizedandsecretedinmonomericformaszymogen.ThestructureisalmostsimilartoMMP2,anothermemberofmatrixmetalloproteinasefamily.
Likeotherproteolyticenzymes,MMP-9isfirstsynthesizedasinactiveproenzymeorzymogens.ActivationofproMMP-9ismediatedbyplasminogenactivator/plasmin(PA/plasmin)system.TheregulationofMMP-9activityisalsocontrolledthroughTIMP-3.
MMP-9playsanimportantroleintumorinvasion,angiogenesisandmetastasis.IncreasedlevelsofMMP-9havebeendemonstratedincolorectalcancer,inacuteleukemia,breastcancer,humanmelanomaandbladdercancer.MMP-9potentiatespulmonarymetastasisformationandgliomainvasion.Apartfromitsfunctionintumorformationandspread,MMP-9withitsdestructiveeffectsisincloseassociationwithlungdiseasesandasthma.LeukocyterecruitmenttothecentralnervoussystemMMP-9meansaninvolvementinthepathogenesisofmultiplesclerosis.MMP-9hasacrucialroleinreproductiveendocrinologyandshowsachangedexpressionpatternaftermyocardialinfarction.
Synonyms:92kDagelatinase,GelatinaseB,GELB
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Likeotherproteolyticenzymes,MMP-9isfirstsynthesizedasinactiveproenzymeorzymogens.ActivationofproMMP-9ismediatedbyplasminogenactivator/plasmin(PA/plasmin)system.TheregulationofMMP-9activityisalsocontrolledthroughTIMP-3.
MMP-9playsanimportantroleintumorinvasion,angiogenesisandmetastasis.IncreasedlevelsofMMP-9havebeendemonstratedincolorectalcancer,inacuteleukemia,breastcancer,humanmelanomaandbladdercancer.MMP-9potentiatespulmonarymetastasisformationandgliomainvasion.Apartfromitsfunctionintumorformationandspread,MMP-9withitsdestructiveeffectsisincloseassociationwithlungdiseasesandasthma.LeukocyterecruitmenttothecentralnervoussystemMMP-9meansaninvolvementinthepathogenesisofmultiplesclerosis.MMP-9hasacrucialroleinreproductiveendocrinologyandshowsachangedexpressionpatternaftermyocardialinfarction.
Synonyms:92kDagelatinase,GelatinaseB,GELB
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