IBL/白细胞介素-10（IL-10）高灵敏度ELISA/BE58101/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x1h,1x15min,1x30min,1x10-20min |
| Standardrange | 0.39-25pg/ml |
| Specimen/Volumes | 50µlserum,plasma,cellculturesupernatants |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Interleukin-10(IL-10)HighSensitivityELISA
ThisHighSensitivityELISAenablestheanalysisofInterleukin-10inlowconcentrationsfromserum,plasma,orcellculturesamples.TheHighSensitivityELISAKitsofferaccuratequantificationbelowconventionalELISAlimits.ThisismadepossIBLebytheirinherentdesignbyamplifyingthesignal.
Interleukin-10isapleiotropiccytokineplayinganimportantroleasaregulatoroflymphoidandmyeloidcellfunction.InhumansIL-10isproducedbyactivatedCD8(+)peripheralbloodT-cells,byT-helperCD4(+)T-cellclones.DuetotheABIlityofIL-10toblockcytokinesynthesisandseveralaccessorycellfunctionsofmacrophagesthiscytokineisapotentsuppressoroftheeffectorfunctionsofmacrophages,T-cellsandNKcells.Inaddition,IL-10participatesinregulatingproliferationanddifferentiationofB-cells,mastcellsandthymocytes.Basedonitsprimarystructure,IL-10isamemberofthefoura-helixbundlefamilyofcytokines.InsolutionhumanIL-10isahomodimerwithanapparentmolecularmassof39kDa.AlthoughitcontainsanN-linked,glycosylationsite,itlacksdetectablecarbohydrates.RecombinantproteinexpressedinE.colithusretainsallknownBIOLOGicalactivities.ThehumanIL-10geneislocatedonchromosome1andispresentasasinglecopyinthegenome.ThehumanIL-10exhibitsstrongDNAandaminoacidsequencehomologytothemurineIL-10andanopenreADIngframeintheEpstein-Barrvirusgenome,BCRF1whichsharesmanyofthecellularcytokine"sbiologicalactivitiesandmaythereforeplayaroleinthehost-virusinteraction.TheimmunosuppressivepropertiesofIL-10suggestapossibleclinicaluseofIL-10insuppressingrejectionsofgraftsafterorgantransplantations.IL-10canfurThermoreexertstronganti-inflammatoryactivities.
Synonyms:Cytokinesynthesisinhibitoryfactor,CSIF
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Interleukin-10isapleiotropiccytokineplayinganimportantroleasaregulatoroflymphoidandmyeloidcellfunction.InhumansIL-10isproducedbyactivatedCD8(+)peripheralbloodT-cells,byT-helperCD4(+)T-cellclones.DuetotheABIlityofIL-10toblockcytokinesynthesisandseveralaccessorycellfunctionsofmacrophagesthiscytokineisapotentsuppressoroftheeffectorfunctionsofmacrophages,T-cellsandNKcells.Inaddition,IL-10participatesinregulatingproliferationanddifferentiationofB-cells,mastcellsandthymocytes.Basedonitsprimarystructure,IL-10isamemberofthefoura-helixbundlefamilyofcytokines.InsolutionhumanIL-10isahomodimerwithanapparentmolecularmassof39kDa.AlthoughitcontainsanN-linked,glycosylationsite,itlacksdetectablecarbohydrates.RecombinantproteinexpressedinE.colithusretainsallknownBIOLOGicalactivities.ThehumanIL-10geneislocatedonchromosome1andispresentasasinglecopyinthegenome.ThehumanIL-10exhibitsstrongDNAandaminoacidsequencehomologytothemurineIL-10andanopenreADIngframeintheEpstein-Barrvirusgenome,BCRF1whichsharesmanyofthecellularcytokine"sbiologicalactivitiesandmaythereforeplayaroleinthehost-virusinteraction.TheimmunosuppressivepropertiesofIL-10suggestapossibleclinicaluseofIL-10insuppressingrejectionsofgraftsafterorgantransplantations.IL-10canfurThermoreexertstronganti-inflammatoryactivities.
Synonyms:Cytokinesynthesisinhibitoryfactor,CSIF
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