IBL/sCD40 ELISA/BE59161/
市场价:
¥0.00
美元价:
0.00
产品分类:
夹心法ELISA
公司分类:
Sandwich_method_ELISA
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Kit size | 12 x 8 |
Method | ELISA |
Incubation time | 1 x 2 h, 1 x 1 h, 1 x 10 min |
Standard range | 7.8 - 500 pg/mL |
Specimen / Volumes | 50 µL serum, plasma, cell culture supernatant et al. |
Substrate / isotope | TMB 450 nm |
Regulatory Status: | For research use only |
Details for:
sCD40 ELISA
CD40 is a 50 kDa membrane-bound type I glycoprotein expressed by numerous cells, most notably B lymphocytes and monocytes and antigen presenting cells (APC) such as macrophages, dendritic cells and fibroblasts. It is furthermore highly expressed on various malignant cells. The expression of CD40 regulates T-cell - APC interaction and has been shown to be centrally involved in a wide array of inflammatory events. The function of CD40 is very broad. CD40 belongs to the TNF-receptor family. The ligand for CD40 (CD154) is a 33 kDa type II transmembrane protein mainly expressed by activated T-cells, and is a member of the TNF superfamily. CD40/CD40L interactions are essential for T-cell-dependent B cell proliferation and differentiation, for activation of antigen presenting cells and for cytokine production on numerous other cells. It is presently accepted that CD40 plays a critical role in the regulation of immune responses. CD40 expression has also been found on non lymphoid cells such as fibroblasts, endothelia, and epithelial cells. CD40 is also involved in the apoptotic pathway of cells. While it has been shown that the programmed cell death can be inhibited by the survival signals mediated from the binding of the CD40 receptor to the CD40 Ligand, very recently a novel proapoptotic mechanism induced by CD40 in carcinoma cells has been described. This mechanism is dependent on the endogenous production of cytotoxic cytokines. The interaction of CD40 and its ligand, CD154 (CD40L) was found to play a crucial role in many aspects of immune response and the development and progress of various diseases: transplant rejection, thyroid diseases, inflammatory events such as multiple sclerosis, atherosclerosis and asthma associated airway inflammation.
Synonyms: Tumor necrosis factor receptor superfamily member 5, CD40L receptor, B-cell surface antigen CD40, Bp50, CD antigen CD40
For concrete data please consult the Instruction for Use in the download box on the right side. Synonyms: Tumor necrosis factor receptor superfamily member 5, CD40L receptor, B-cell surface antigen CD40, Bp50, CD antigen CD40
品牌介绍
IBL我们的愿景是通过Tecan技术,产品和支持,为世界各地的每个实验室提供支持。我们旨在通过无与伦比的专业知识,产品和客户支持来塑造生命科学和临床诊断自动化工作流程的未来。