4000-520-616
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商品详细IBL/肾素活性发光免疫分析/DB69011/
IBL/肾素活性发光免疫分析/DB69011/
IBL/肾素活性发光免疫分析/DB69011/
商品编号: DB69011
品牌: TECAN
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 其它检测试剂盒
公司分类: Other_kits
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Kitsize12x8
MethodLuminescenceImmunoassay
Incubationtime1x1h,1x30min
Standardrange0.2-60ng/mL
Specimen/Volumes500µLEDTAPasma
Substrate/isotopeLuminol
RegulatoryStatus:RUO,EU:CE
Detailsfor: ReninactivityLuminescenceImmunoassay
LuminescenceImmunoassayforthequantitativedeterminationofPlasmaReninActivity(PRA)inhumanplasma.

MeasurementofPRAisimportantfortheclinicalevaluationofhypertensivepatients.Inparticular,determinationofplasmareninactivitycanhelpinthediagnosisofprimaryhyperaldosteronism(5-13%ofhypertensivecases)andassistinthetherapyandmanagementofotherformsofhypertension.

PRA,incontrasttothedeterminationofreninconcentration,isamoreaccurateindicatorofprimaryhyperaldosteronism(PHA),becauseofseveralreasons:

1.PRAistheexpressionoftherateofAng-Iformationthroughtheenzymaticactionofreninonitssubstrate,angiotensinogen,thereforePRAdependsnotonlyonreninconcentrationbutalsoontheconcentrationofangiotensinogenwhichisignoredinthereninconcentrationassay;

2.Plasmareninconcentrationassaydoesnotensuresensitivityinlowreninstates,whilethesensitivityofthePRAassaycanbeenhancedbyincreasingtheincubationtimeduringthegenerationstep(Sealeyetal.,2005),

3.WhenaninhibitorisboundtothereninactivesitePRAisinhibited,whereasthepresenceoftheinhibitordoesnotaffecttherecognitionofreninbycurrentlyavailableimmunoassays,thereforetotalreninconcentrationdoesnotalwayscorrelatewithplasmareninactivity(Campbelletal.,2009).

Reninliberatesangiotensin-Ifromangiotensinogen.Angiotensin-Iistransformedtoangiotensin-IIlargelyinpulmonarycirculationbyangiotensinconvertingenzyme(ACE).Angiotensin-IIraisesbloodpressurebydirectarteriolarvasoconstriction,promotingsodiumretension,andstimulatingthesecretionofaldosteronefromtheadrenalcortex.Aldosteronealsoexertsaneffecttorestoresodiumbalanceandliftarterialpressure.Accuratemeasurementoftheconcentrationofcirculatingangiotensin-IIischallengingbecauseofitsinstABIlityinbloodsamples.Aldosteroneconcentrationcanbeeasilydeterminedusingtheimmunoassaykit.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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