IBL/肾素活性IRMA（CT）/MG11101/
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商品介绍
| Kitsize | 96 |
| Method | IRMA(CT) |
| Incubationtime | 1x3h |
| Standardrange | 4-520pg/mL |
| Specimen/Volumes | 300µLEDTAPlasma |
| Substrate/isotope | 125I<760kBq |
| RegulatoryStatus: | EU:CE |
Detailsfor:ReninactiveIRMA(CT)
ImmunorADIometricassaykitforthequantitativedeterminationofactiveRenininhumanEDTAplasma.
Renin,apolypeptidicenzyme(MW~40000)alsoknownasangiotensinogenase,isacirculatingproteasesecretedbyjuxtaglomerularcellsinthejuxtaglomerularapparatusofthekidneysinresponsetolowbloodvolumeorlowbodyNaCLcontent.
Reninactivatestherenin-angiotensinsystembycleavingangiotensinogenproducedintheliverintoangiotensinI(inactive)whichisfurtherconvertedintoangiotensinII(active)inthevascularepitheliumofthelung.AngiotensinIIcancausevasoconstrictionbystimulatingthecentralnervoussystem,inadditionitstimulatesADH(antidiuretichormone)secretionandaldosteronesecretionfromtheadrenalgland.Regulationofbloodpressureandrenalglomerularfiltrationcontrolarethemostimportantfunctionsofrenin-angiotensinsystem.
PlasmaticconcentrationofreninisinfluencedbyconcentrationofcirculatingangiotensinogenandsubsequentlytheconcentrationofangiotensinII.HighplasmaticlevelsofangiotensinIIreducereninsecretion.(negativefeedback).
Determinationofreninplasmalevelsisusefulinthediagnosisofhypertensionandinthetherapeuticfollowupofhypertensivepatients.
Plasmaticconcentrationofrenindecreasesinpatientswithhypertensionduetoaprimaryhyperaldosteronism,contrarytorenovascularhypertensionwhereconcentrationsofreninandaldosteronearebothelevated.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Renin,apolypeptidicenzyme(MW~40000)alsoknownasangiotensinogenase,isacirculatingproteasesecretedbyjuxtaglomerularcellsinthejuxtaglomerularapparatusofthekidneysinresponsetolowbloodvolumeorlowbodyNaCLcontent.
Reninactivatestherenin-angiotensinsystembycleavingangiotensinogenproducedintheliverintoangiotensinI(inactive)whichisfurtherconvertedintoangiotensinII(active)inthevascularepitheliumofthelung.AngiotensinIIcancausevasoconstrictionbystimulatingthecentralnervoussystem,inadditionitstimulatesADH(antidiuretichormone)secretionandaldosteronesecretionfromtheadrenalgland.Regulationofbloodpressureandrenalglomerularfiltrationcontrolarethemostimportantfunctionsofrenin-angiotensinsystem.
PlasmaticconcentrationofreninisinfluencedbyconcentrationofcirculatingangiotensinogenandsubsequentlytheconcentrationofangiotensinII.HighplasmaticlevelsofangiotensinIIreducereninsecretion.(negativefeedback).
Determinationofreninplasmalevelsisusefulinthediagnosisofhypertensionandinthetherapeuticfollowupofhypertensivepatients.
Plasmaticconcentrationofrenindecreasesinpatientswithhypertensionduetoaprimaryhyperaldosteronism,contrarytorenovascularhypertensionwhereconcentrationsofreninandaldosteronearebothelevated.
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