IBL/Insulin IRMA (CT)/MG13021/
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联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 96 |
| Method | IRMA(CT) |
| Incubationtime | 1x2h |
| Standardrange | 5.7-440µIU/mL |
| Specimen/Volumes | 50µLserum,plasma |
| Substrate/isotope | 125I<350kBq |
| RegulatoryStatus: | EU:CE |
Detailsfor:InsulinIRMA(CT)
InsulinistheprincipalhormoneresponsIBLeforthecontrolofglucosemetabolism.Itissynthesizedintheß-cellsoftheisletsofLangerhansastheprecursor,proinsulin,whichisprocessedtoformC-peptideandinsulin.Botharesecretedinequimolaramountsintotheportalcirculation.Thematureinsulinmoleculecomprisestwopolypeptidechains,theAchainandBchain(21and30aminoacidsrespectively).Thetwochainsarelinkedtogetherbytwointer-chaindisulphidebridges.Thereisalsoanintra-chaindisulphidebridgeintheAchain.Secretionofinsulinismainlycontrolledbyplasmaglucoseconcentration,andthehormonehasanumberofimportantmetabolicactions.Itsprincipalfunctionistocontroltheuptakeandutilisationofglucoseinperipheraltissuesviatheglucosetransporter.Thisandotherhypoglycaemicactivities,suchastheinhibitionofhepaticgluconeogenesisandglycogenolysisarecounteractedbythehyperglycaemichormonesincludingglucagon,epinephrine(adrenaline),growthhormoneandcortisol.Insulinconcentrationsareseverelyreducedininsulin-dependentdiabetesmellitus(IDDM)andsomeotherconditionssuchashypopituitarism.Insulinlevelsareraisedinnon-insulin-dependentdiabetesmellitus(NIDDM),obesity,insulinomaandsomeendocrinedysfunctionssuchasCushing’ssyndromeandacromegaly.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.品牌介绍
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