Glucagonisa29aminoacidsstraightchainpeptideproducedinthepancreatica-cells.Glucagoniscleavedoutfrompreproglucagonwith159aminoacids.Theaminoacidsequenceofglucagonisfoundinglicentin,a69aminoacidpeptide.Glicentinhasbeenproposedtobeabiosyntheticintermediateforpancreaticandgutglucagon.Glucagonisinvolvedincarbohydrate,fatandproteinmetabolism.Basalamountsofglucagonareessentialforthemaintenanceofnormoglycemiaandaphysiologicalroleforglucagonistopreventhypoglycemia.Increasesintheplasmaglucagonlevelaffectglucoseproductionfirstbystimulatingatransientphaseofglycogenolysisandthenaprolongedperiodofglyconeogenesis.Asustainedincreaseintheglucagonlevelcontinuestomodulatehepaticglucoseproduction.Glucagonalsoplaysaroleintheaminoacidmetabolism.Elevationofglucagoninplasmadecreasesaminoacidswhereasglucagondeficiencyincreasesaminoacids.Theaminoacidsequenceofhumanpancreaticglucagon:His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr.