IBL/FGF19 ELISA/JP27996/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x18h,2x30min. |
| Standardrange | 23.4-1500pg/mL |
| Specimen/Volumes | 100µLEDTAplasma,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:FGF19ELISA
TheFGF19subfamilycomposedofFGF15/19,FGF21andFGF23bindstheFGFreceptorsco-joinedbyα-orβ-Klothoanditischaracterizedasafactorgroupwhichhashormonalfunctions.Thenovelsystemconsistedofα/βKlothoandFGF19subfamilyregulatesintegrallymetabolismofminerals,lipids,energyandaminoacids.Thisnovelregulatingsysteminvolvesimportanthomeostaticmechanismsinthebodysuchasbileacidandcholesterolmetabolismintheliver(throughFGF19),energyandglycolipidsmetabolism(throughFGF21)andphosphate,calciumandvitaminDmetabolisminkidney(throughFGF23)infastingstate.
FGF19issecretedintheileum(smallintestine)andtransportedtotheliverthroughthebloodstream.Itsuppressesthesynthesisofbileacidinliverwitheffectsonglucoseandlipidmetabolism.FGF19bindsareceptorunitconsistingofFGFR4andβ-Klotho.
LevelsofFGF19arestudiedinrelationtodigestivedisorderssuchasdiarrheaandconstipationwhichmightberelatedtoFGF19hormonalabnormalityandmetabolicdisorderssuchasdiabetes.LowerlevelsofFGF19arefoundinchronicdiarrheapatients,butalsometabolicsyndrome,non-alcoholicfattyliverdiseaseandinsulinresistance.FGF19isoftenalsomeasuredinquiescentCrohn"scolitis,hepatocellularcarcinoma,anorexianervosaandtype2diabeticpatientswithmetabolicsyndrome.
ThiskitmeasureshumanFGF19in.
Separatecontrolsetavailableonrequest
DistributedbyIBLInternational
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.FGF19issecretedintheileum(smallintestine)andtransportedtotheliverthroughthebloodstream.Itsuppressesthesynthesisofbileacidinliverwitheffectsonglucoseandlipidmetabolism.FGF19bindsareceptorunitconsistingofFGFR4andβ-Klotho.
LevelsofFGF19arestudiedinrelationtodigestivedisorderssuchasdiarrheaandconstipationwhichmightberelatedtoFGF19hormonalabnormalityandmetabolicdisorderssuchasdiabetes.LowerlevelsofFGF19arefoundinchronicdiarrheapatients,butalsometabolicsyndrome,non-alcoholicfattyliverdiseaseandinsulinresistance.FGF19isoftenalsomeasuredinquiescentCrohn"scolitis,hepatocellularcarcinoma,anorexianervosaandtype2diabeticpatientswithmetabolicsyndrome.
ThiskitmeasureshumanFGF19in.
Separatecontrolsetavailableonrequest
DistributedbyIBLInternational
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