IBL/牙本质基质蛋白1 ELISA/30121797/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x18h,1x1h,1x30min. |
| Standardrange | 3.6-230pmol/L |
| Specimen/Volumes | 10µLserum,plasma,urine,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:DentinMatrixProtein1ELISA
"Originalarticle#27261
DentinMatrixProtein1(DMP1)isaconstitutiveproteinintheextracellularmatrixofosteocytesanditbelongstotheSmallIntegrin-BindingLigand,N-linkedGlycoprotein(SIBLING)family.Itissynthesizedasafull-length105kDaproproteinandisdividedintoa37kDaNterminalproteinfragmentanda57kDaCterminalproteinfragmentduringthesecretionprocess.Ithasalotofacidicdomainsanditbindswithcalciumasitbecomesnegativelychargedwithintissuesandithasanimportantroleforbonemineralization.DMP1expressesinosteocyteswhileotherconstitutiveproteinsintheextracellularmatrixsuchasOsteopontin,OsteocalcinandBonesialoproteinexpressinosteoblastcells.Osteocyteswhicharethemainconstituentcellsofboneregulateactivitiesofosteoclasticcellsandosteoblastcellsanditadjuststheboneremodelingprocess.Theyalsoactasendocrinecells,whichsecreteFGF-23.DMP1inbloodisconsideredasacandidatebioMarkerreflectingosteocyteactivityanditisalsosuggestedtoaddusefulinformationforresearchofbonemetabolismandphosphatemetabolism.TheconcentrationofDMP1inhumanbloodcanbequantitativelymeasuredbythisELISAkit."
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.DentinMatrixProtein1(DMP1)isaconstitutiveproteinintheextracellularmatrixofosteocytesanditbelongstotheSmallIntegrin-BindingLigand,N-linkedGlycoprotein(SIBLING)family.Itissynthesizedasafull-length105kDaproproteinandisdividedintoa37kDaNterminalproteinfragmentanda57kDaCterminalproteinfragmentduringthesecretionprocess.Ithasalotofacidicdomainsanditbindswithcalciumasitbecomesnegativelychargedwithintissuesandithasanimportantroleforbonemineralization.DMP1expressesinosteocyteswhileotherconstitutiveproteinsintheextracellularmatrixsuchasOsteopontin,OsteocalcinandBonesialoproteinexpressinosteoblastcells.Osteocyteswhicharethemainconstituentcellsofboneregulateactivitiesofosteoclasticcellsandosteoblastcellsanditadjuststheboneremodelingprocess.Theyalsoactasendocrinecells,whichsecreteFGF-23.DMP1inbloodisconsideredasacandidatebioMarkerreflectingosteocyteactivityanditisalsosuggestedtoaddusefulinformationforresearchofbonemetabolismandphosphatemetabolism.TheconcentrationofDMP1inhumanbloodcanbequantitativelymeasuredbythisELISAkit."
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