IBL/Estron RIA(CT)/MG13001/
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商品介绍
Kitsize | 100 |
Method | RIA(CT) |
Incubationtime | 1x2h |
Standardrange | 12.5-750pg/mL |
Specimen/Volumes | 100µLserum,plasma |
Substrate/isotope | 125I<185kBq |
RegulatoryStatus: | EU:CE |
Detailsfor: EstronRIA(CT)
Innormalwomen,mostplasmaestrADIolisderivedfromtheovary,wherethecacellssecreteandrostenedione,whichisthenconvertedtoestroneandthentoestradiolbythegranulosacells.Littleestroneisindeedformedandsecretedbytheovary:mostoriginatesfromaperipheralconversionofestradiolandfromthearomatisationofandrostenedione,acatalyticreactionessentiallycarriedoutinadiposetissue.Inpremenopausalwomen,androstenedioneissecretedbytheovaryandtheadrenals.Inpregnantwomen,thefetaladrenalglandprovidesasignificantcontributiontoandrostenedioneproduction.Inmenopausalwomen,estroneistheessentialestrogenfoundinthecirculation,resultingfromtheconversionofadrenalandrostenedione.Anincreaseinestrogenformationoccurswithagingandincorrelationwiththeamountofadiposetissue.Theestrogeniceffectsofestroneinmenopausalwomencanproduceendometrialhyperplasiaandbleedingbutalsomaintainsthebonemineralcontent.Inpremenopausalwomen,excessiveestronebloodlevelscanresultfromtheconversionoflargeamountsofandrostenedioneproducedinmicropolycysticovarysyndromeandovariantumors.Insuchwomen,highestronebloodlevelscanparticipateinadisturbanceofthemenstrualcycle.Estroneinthecirculationisessentiallyboundtoalbumin.Thisisimportantintheinterpretationofestrone-assaydata.Indeed,andcontrarytoestradiol,totalestronelevelsarenotsignificantlymodifiedbySHBGconcentration
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.品牌介绍
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