IBL/抗Dock8兔IgG亲和纯化/JP28113/
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商品介绍
| Quantity/Tests | 100µg |
| Species/Antigen | Syntheticpeptide |
| Host | Rabbit |
| Subclass/Clone | N/A |
| Type | N/A |
| Purification | Purifiedwithantigenpeptide |
| Label | N/A |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-Dock8RabbitIgGAffinityPurify
SmallGTPaseofRhofamilyisoneofsignalingfactorswhichcontrolalterationofcellularmorphology,celldivisionanddifferentiation,andplaysanimportantroleinregulationofgenerationandorganogenesisatanindividuallevel.Itsfunctionsarestrictlyregulatedanditsdysfunctioncausesmanydiseasessuchasimmunologicaldiseaseorneurodegenerativedisease.
Dedicatorofcytokinesis(Dock)8isaRhofamilysmallGTPaseactivatingfactor(orexchangefactor)activatingRac1andCdc42specificallyoftheRhofamilysmallGTPase.ItisconsideredthatDock8isanimportantfactorforproliferationanddifferentiationofimmnocytes,neurocytesandstemcellssinceitismoreexpressedespeciallyinimmunesystem,nervetissuesandtissuesoffetalstage.ItisknownasaresponsIBLegeneforhyper-IgEsyndrome,andmanytypesofgeneticmutationshavebeenreported.Additionally,relationwithbloodtumorshasbeenpointedout.
Thereareproteins,calledDock6andDock7,verysimilartoDock8inhumanbuttherearestillmanyunclearpointsabouttheirregulationsystems.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Dedicatorofcytokinesis(Dock)8isaRhofamilysmallGTPaseactivatingfactor(orexchangefactor)activatingRac1andCdc42specificallyoftheRhofamilysmallGTPase.ItisconsideredthatDock8isanimportantfactorforproliferationanddifferentiationofimmnocytes,neurocytesandstemcellssinceitismoreexpressedespeciallyinimmunesystem,nervetissuesandtissuesoffetalstage.ItisknownasaresponsIBLegeneforhyper-IgEsyndrome,andmanytypesofgeneticmutationshavebeenreported.Additionally,relationwithbloodtumorshasbeenpointedout.
Thereareproteins,calledDock6andDock7,verysimilartoDock8inhumanbuttherearestillmanyunclearpointsabouttheirregulationsystems.
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