IBL/抗人CD109(461)兔IgG/JP28119/
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3392242852
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4000-520-616
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商品介绍
Quantity/Tests | 100µg |
Species/Antigen | SyntheticpeptideofapartofHumanCD109(aa461-478) |
Host | Rabbit |
Subclass/Clone | IgG |
Type | Polyclonal |
Purification | Affinitypurifiedwithantigenpeptide |
Label | No |
RegulatoryStatus: | Forresearchuseonly |
Detailsfor: Anti-HumanCD109(461)RabbitIgG
CD109isaglycosyl-phosphatidyl-inositol(GPI)-anchoredglycoproteinsizedabout180-190kDa.IthasbeenshownthatCD109isexpressedinvascularendothelialcells,someepithelialcells,activatedT-cellsandplatelets,andasubsetofCD34+megakaryocyticleukemiacells.TheCD109moleculesarestronglyexpressedinKG1acells,whileCD34+CD109+cellsinfetalbonemarrowincludealmostallmyelocytic,erythroblasticandmegakaryocyticprecursorcells.Forthisreason,CD109isconsideredtobeaMarkerofmegakaryocytichematopoiesisinearlystage.FurThermore,CD109isconsideredtobedifferentfromexistingactivationmarkersofleukocytesandplatelets,becauseofitsstructureandSEROlogicalfeatures.
ByreportsofTakahashietal.,CD109issignificantlyoverexpressedinsquamouscellcarcinomaoflungtissue,esophagealtissueanduterinecervicaltissue.Thus,itisattractingattentioninstudyingsquamouscellcarcinoma.Additionally,arecentstudysuggeststhatCD109isinvolvedintheregulationoftransforminggrowthfactor(TGF)-βsignalinginsomecancercellsandkeratinocytes.
DistributedbyIBLInternational
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.ByreportsofTakahashietal.,CD109issignificantlyoverexpressedinsquamouscellcarcinomaoflungtissue,esophagealtissueanduterinecervicaltissue.Thus,itisattractingattentioninstudyingsquamouscellcarcinoma.Additionally,arecentstudysuggeststhatCD109isinvolvedintheregulationoftransforminggrowthfactor(TGF)-βsignalinginsomecancercellsandkeratinocytes.
DistributedbyIBLInternational
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