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主营:主营:血管内皮生长因子-C, Spp1, IRF-3, DPYSL2, GLUT5
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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > IBL/sVE钙粘蛋白(猴)ELISA/BE45761/
商品详细IBL/sVE钙粘蛋白(猴)ELISA/BE45761/
IBL/sVE钙粘蛋白(猴)ELISA/BE45761/
IBL/sVE钙粘蛋白(猴)ELISA/BE45761/
商品编号: BE45761
品牌: TECAN
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Kitsize12x8
MethodELISA
Incubationtime1x2h,1x1h,1x10min
Standardrange0.19-12.5U/mL
Specimen/Volumes50µLserum,plasma,cellculturesupernatantetal.
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: sVE-Cadherin(monkey)ELISA
Cadherin-5,thoughmemberofthefamilyofcadherinshasbeenshowntobefunctionallyaswellasstructurallydistinctfromclassicalcadherins(e.g.E-,N-,P-cadherins).Throughitsfunctionandlocationcadherin-5hasbeennamedVE-cadherin.Itsaproteinofarelativemolecularmassofabout130kDa.Thevascularendothelialcadherin(VE-cadherin)geneencodesaCa2+-dependentcelladhesionmoleculerequiredfortheorganizationofinterendothelialjunctions.VE-cadherinmediateshomophilic,calcium-dependentaggregationandcell-to-celladhesion.Inaddition,itdecreasesintercellularpermeABIlitytohigh-molecularweightmoleculesandreducescellmigrationrateacrossawoundedarea.VE-cadherinisatransmembraneprotein,theintracellulardomainhasbeenshowntointeractwithcytoplasmicproteinscalledcateninsthattransmittheadhesionsignaluponthisactivation.SotheVE-cadherinextracellulardomainisenoughforearlystepsofcelladhesionandrecognition.However,interactionofVE-cadherintheCytoskeleton,mediatedthroughthecytoplasmaticdomain,isnecessarytoprovidestrengthandcohesiontothejunction.Theinitiationofendothelialapoptosiscorrelateswithcleavageanddisassemblyofcomponentsofadherensjunctions.TheextracellularportionofthesejunctionsisalteredduringapoptosisbecauseVE-cadherindramaticallydecreasesonthesurfaceofcells.AnextracellularfragmentofVE-cadherincanbedetected.ThissheddingofVE-cadherincanbeblockedbyaninhibitorofmetalloproteinases.Itmaybepartofaconcertedmechanismtodisruptstructuralandsignalingpropertiesofadherensjunctionsandmayactivelyinterruptextracellularsignalsrequiredforendothelialcellsurvival.

Synonyms:Vascularendothelial-cadherin,7B4antigen,CD144
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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