IBL/sVE钙粘蛋白(猴)ELISA/BE45761/
市场价:
¥0.00
美元价:
0.00
产品分类:
夹心法ELISA
公司分类:
Sandwich_method_ELISA
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Kitsize | 12x8 |
Method | ELISA |
Incubationtime | 1x2h,1x1h,1x10min |
Standardrange | 0.19-12.5U/mL |
Specimen/Volumes | 50µLserum,plasma,cellculturesupernatantetal. |
Substrate/isotope | TMB450nm |
RegulatoryStatus: | Forresearchuseonly |
Detailsfor: sVE-Cadherin(monkey)ELISA
Cadherin-5,thoughmemberofthefamilyofcadherinshasbeenshowntobefunctionallyaswellasstructurallydistinctfromclassicalcadherins(e.g.E-,N-,P-cadherins).Throughitsfunctionandlocationcadherin-5hasbeennamedVE-cadherin.Itsaproteinofarelativemolecularmassofabout130kDa.Thevascularendothelialcadherin(VE-cadherin)geneencodesaCa2+-dependentcelladhesionmoleculerequiredfortheorganizationofinterendothelialjunctions.VE-cadherinmediateshomophilic,calcium-dependentaggregationandcell-to-celladhesion.Inaddition,itdecreasesintercellularpermeABIlitytohigh-molecularweightmoleculesandreducescellmigrationrateacrossawoundedarea.VE-cadherinisatransmembraneprotein,theintracellulardomainhasbeenshowntointeractwithcytoplasmicproteinscalledcateninsthattransmittheadhesionsignaluponthisactivation.SotheVE-cadherinextracellulardomainisenoughforearlystepsofcelladhesionandrecognition.However,interactionofVE-cadherintheCytoskeleton,mediatedthroughthecytoplasmaticdomain,isnecessarytoprovidestrengthandcohesiontothejunction.Theinitiationofendothelialapoptosiscorrelateswithcleavageanddisassemblyofcomponentsofadherensjunctions.TheextracellularportionofthesejunctionsisalteredduringapoptosisbecauseVE-cadherindramaticallydecreasesonthesurfaceofcells.AnextracellularfragmentofVE-cadherincanbedetected.ThissheddingofVE-cadherincanbeblockedbyaninhibitorofmetalloproteinases.Itmaybepartofaconcertedmechanismtodisruptstructuralandsignalingpropertiesofadherensjunctionsandmayactivelyinterruptextracellularsignalsrequiredforendothelialcellsurvival.
Synonyms:Vascularendothelial-cadherin,7B4antigen,CD144
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Synonyms:Vascularendothelial-cadherin,7B4antigen,CD144
品牌介绍
IBL我们的愿景是通过Tecan技术,产品和支持,为世界各地的每个实验室提供支持。我们旨在通过无与伦比的专业知识,产品和客户支持来塑造生命科学和临床诊断自动化工作流程的未来。