IBL/sP-Selectin (monkey) ELISA/BE45741/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x10min |
| Standardrange | 2.3-150U/mL |
| Specimen/Volumes | 10µLserum,plasma,cellculturesupernatantetal. |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:sP-Selectin(monkey)ELISA
P-selectinbelongstotheselectinfamilyofadhesionmolecules.P-selectinactsasareceptorthatsupportsbindingofleukocytestoactivatedplateletsandendothelium.P-selectinisa140kDaproteinthatishighlyglycosylated.TheCDNAderivedaminoacidsequencepredictsamoleculewithaseriesofcysteine-richdomains.P-selectinislocatedinmembranesofagranulesinunstimulatedplateletsandredistributedtothecellsurfaceuponplateletactivation.P-selectinisalsopresentinendothelialcellsinmembranesofWeibel-Paladebodiesandmegakaryocytes.ThephysiologicroleofP-selectinmightbethemediationofinitialleukocyteadhesiontoactivatedendotheliumduringacuteinflammation.ItmayworkinconcertwithE-selectintodirectearly,regionallyspecificadherenceofneutrophilsandmonocytesatsitesofacuteinflammation.AsolubleformofP-selectinfoundinserumandplasmahasbeendescribedwhichmightrepresentaproteolyticfragmentormorelikelyasolublesplicevariantlackingthetransmembranedomain.
ExcessiveaccumulationofneutrophilsontheendothelialsurfaceaccompaniedbyhighexposureofP-selectinhasbeenimplicatedinanumberofinflammatorydisorders,includingadultrespiratorydistresssyndrome,acutelunginjury,ischemia-reperfusioninjury,Gram-negativesepticshock,thromboticdiseasesandrheumatoidarthritis.MalignantcellswereshowntoexpressreceptorsforP-selectinsuggestinganimportantroleforP-selectinintumorformationandmetastasis.
Synonyms:Granulemembraneprotein140,PADGEM,CD62P
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.ExcessiveaccumulationofneutrophilsontheendothelialsurfaceaccompaniedbyhighexposureofP-selectinhasbeenimplicatedinanumberofinflammatorydisorders,includingadultrespiratorydistresssyndrome,acutelunginjury,ischemia-reperfusioninjury,Gram-negativesepticshock,thromboticdiseasesandrheumatoidarthritis.MalignantcellswereshowntoexpressreceptorsforP-selectinsuggestinganimportantroleforP-selectinintumorformationandmetastasis.
Synonyms:Granulemembraneprotein140,PADGEM,CD62P
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