IBL/IL-8/IL-8（猴）ELISA/BE45581/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
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3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x10min |
| Standardrange | 19-1250U/mL |
| Specimen/Volumes | 50µLserum,plasma,cellculturesupernatantetal. |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Interleukin-8/IL-8(monkey)ELISA
Interleukin-8selectivelystimulatestheABIlityofneutrophilsandT-lymphocytestoinvadeinjuredorinflamedtissue.IL-8alsoknownasCXCL8thatispurifiedfromperipheralbloodmonocytesisa10kDaproteinshowingatleast4variantforms(77,72,70,and69aminoacids,respectively)whichdifferinthelengthoftheN-terminalandreADIlyformdimersinsolution.Twocystin-bridgesareessentialfortheBIOLOGicalactivityofIL-8.ExogenousstimulilikeLPS,butalsoIL-1,TNF-alphaandTNF-betainducethesecretionofIL-8inavarietyofdifferentcelltypesincludingmonocytes,endothelialandepithelialcells,peripheralbloodmononuclearcells,dermalfibroblasts,keratinocytes,neutrophils,hepatocytes,synovialcells,andT-lymphocytes.TheactivitiesofIL-8arenotspecies-specific.HumanIL-8isalsoactiveinrodentandrabbitcellsanddiffersfromallothercytokinesinitsabilitytospecificallyactivateneutrophilgranulocytes.Thischemokineactivatesmultipleintracellularsignalingpathwaysdownstreamoftwocell-surface,Gprotein-coupledreceptors(CXCR1andCXCR2).ThepropertyofIL-8tostimulatemovementofneutrophilsacrossendothelialmonolayersinvitrosupportstheconceptofacentralroleforthismoleculeintheaccumulationofneutrophilsatinflammatorylesionsinvivo.
Synonyms:Protein3-10C,CXCL8,NAP-1,GCP-1
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Synonyms:Protein3-10C,CXCL8,NAP-1,GCP-1
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