IBL/IL-18/IL-18（猪）ELISA/BE45981/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
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3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x1h,1x10min |
| Standardrange | 39.1-2500pg/mL |
| Specimen/Volumes | 50µLserum,plasma,cellculturesupernatantetal. |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Interleukin-18/IL-18(swine)ELISA
Formerlycalledinterferongammainducingfactor(IGIF),IL-18isacytokinethatplaysanimportantroleintheTh1response,primarilybyitsABIlitytoinduceIFNgammaproductioninTcellsandnaturalkillercells.
Intermsofstructure,IL-18andIL-1betashareprimaryaminoacidsequencesoftheso-called"signaturesequence"motifandaresimilarlyfoldedasallbetapleatedsheetmolecules.AlsosimilartoIL-1beta,IL-18issynthesizedasaBIOLOGicallyinactiveprecursormoleculelackingasignalpeptidewhichrequirescleavageintoanactive,maturemoleculebytheintracellularcysteineproteasecalledIL-1beta-convertingenzyme(ICE,caspase-1).TheactivityofthematureIL-18iscloselyrelatedtothatofIL-1.
TheactivityofIL-18isviaanIL-18receptorcomplex.IL-18inducesgeneexpressionandsynthesisofTNF,IL-1,FasLigand,andseveralchemokines.SimilartoIL-1,IL-18participatesinbothinnateandacquiredimmunity.
Synonyms:Interleukin-18,Interferon-gamma-inducingfactor
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Intermsofstructure,IL-18andIL-1betashareprimaryaminoacidsequencesoftheso-called"signaturesequence"motifandaresimilarlyfoldedasallbetapleatedsheetmolecules.AlsosimilartoIL-1beta,IL-18issynthesizedasaBIOLOGicallyinactiveprecursormoleculelackingasignalpeptidewhichrequirescleavageintoanactive,maturemoleculebytheintracellularcysteineproteasecalledIL-1beta-convertingenzyme(ICE,caspase-1).TheactivityofthematureIL-18iscloselyrelatedtothatofIL-1.
TheactivityofIL-18isviaanIL-18receptorcomplex.IL-18inducesgeneexpressionandsynthesisofTNF,IL-1,FasLigand,andseveralchemokines.SimilartoIL-1,IL-18participatesinbothinnateandacquiredimmunity.
Synonyms:Interleukin-18,Interferon-gamma-inducingfactor
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