IBL/IL-17AF/IL-17AF(小鼠)ELISA/BE45071/
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产品分类:
夹心法ELISA
公司分类:
Sandwich_method_ELISA
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3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Kitsize | 12x8 |
Method | ELISA |
Incubationtime | 1x2h,1x1h,1x30min |
Standardrange | 3.9-250pg/mL |
Specimen/Volumes | 50µLserum,plasma,cellculturesupernatantetal. |
Substrate/isotope | TMB450nm |
RegulatoryStatus: | Forresearchuseonly |
Detailsfor: Interleukin-17AF/IL-17AF(mouse)ELISA
IL-17AandIL-17FaremembersoftheIL-17familyandsignatureTh17cytokines.OfthesixIL-17familymembers,IL-17FandIL-17Asharethestrongesthomology(50%aminoacididentity)andthetwogenesarelocatedinthesamechromosomalregion.AlthoughbothIL-17AandIL-17Fwereoriginallyfoundtobeproducedasdisulfide-linkedhomodimers,recentstudieshaveconfirmedtheproductionofIL-17AFheterodimersininvitro-differentiatedandpolarizedTh17cells.ActivatedhumanCD4+TcellsinculturewerefoundtosecretetheIL-17Fhomodimerat10-foldhigherlevelsthantheIL-17Ahomodimer,suggestingthatthemajorityoftheIL-17AproteinexpressedexistsintheformoftheIL-17AFheterodimer.StudiesofTh17-polarizedmousesplenocytesalsoindicatethatthemajorityofIL-17producediscomplexedastheIL-17AFheterodimer.IL-17FandIL-17Ahavebeenobservedintissuesamplesfromvariousautoimmunediseases,suchasrheumatoidarthritis,multiplesclerosis,psoriasis,inflammatoryboweldisease,andasthma.
Synonyms:Interleukin17AF,IL-17A/Fheterodimer
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Synonyms:Interleukin17AF,IL-17A/Fheterodimer
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