
IBL/IL-13/IL-13(小鼠)ELISA/BE45141/
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产品分类:
夹心法ELISA
公司分类:
Sandwich_method_ELISA
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3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Kitsize | 12x8 |
Method | ELISA |
Incubationtime | 1x2h,1x1h,1x10min. |
Standardrange | 7.8-500pg/ml |
Specimen/Volumes | 50µlserum,plasma,cellculturesupernatant |
Substrate/isotope | TMB450nm |
RegulatoryStatus: | Forresearchuseonly |
Detailsfor: Interleukin-13/IL-13(mouse)ELISA
Interleukin-13isaTh4-typecytokine,secretedfromCD4(+)Tcells,mastcells,basophilsandeosinophils.TheIL-13genegeneratesaclusterwithotherTh4-typecytokinessuchasIL-4andIL-5.IL-13isanimmunoregulatorycytokineandakeymediatorinthepathogenesisofallergicinflammation.ItmediatesitseffectsbyinteractingwithacomplexreceptorsystemcomprisedofIL-4RalphaandtwoIL-13bindingproteins,IL-13Ralpha1andIL-13Ralpha2.IL-13receptorsareexpressedonhumanBcells,basophils,eosinophils,mastcells,endothelialcells,fibroblasts,monocytes,macrophages,respiratoryepithelialcells,andsmoothmusclecells.However,functionalIL-13receptorshavenotbeendemonstratedonhumanormouseTcells.ThusunlikeIL-4,IL-13doesnotappeartobeimportantintheinitialdifferentiationofCD4TcellsintoT(H)2-typecellsbutratherappearstobeimportantintheeffectorphaseofallergicinflammation.TheimportantroleofIL-13inthepathogenesisofbronchialasthmaaswellasotherallergicdiseaseshasbeenrecognized,basedmainlyonanalysesofmousemodels.
Synonyms:ALRH,BHR1,allergicrhinitis
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Synonyms:ALRH,BHR1,allergicrhinitis
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