IBL/IL-12p70/IL-12p70（小鼠）ELISA/BE45131/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x1h,1x10min. |
| Standardrange | 15.6-1000pg/ml |
| Specimen/Volumes | 50µlserum,plasma,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Interleukin-12p70/IL-12p70(mouse)ELISA
Interleukin-12isproducedprimarilybystimulatedmacrophages.IL-12hasbeenshowntobeaproinflammatorycytokineproducedbyphagocyticcells,Bcells,andotherantigen-presentingcellsthatmodulateadaptiveimmuneresponsesbyfavoringthegenerationofT-helpertype1cells.
IL-12exertsavarietyofBIOLOGicaleffectsonTandnaturalkillercells.ApartfrompromotionofTh1developmentanditsABIlitytopromotecytolyticactivityitmediatessomeofitsphysiologicalactivitiesbyactingasapotentinducerofIFN-gammaproductionandthestimulationofothercytokinesfromperipheralbloodTandNKcells.IFN-gammathenenhancestheabilityofthephagocyticcellstoproduceIL-12andotherproinflammatorycytokines.Thus,IL-12inducedIFN-gammaactsinapositivefeedbackloopthatrepresentsanimportantamplifyingmechanismintheinflammatoryresponsetoinfections.
ItsroleindirectingdevelopmentofaTh1typeimmuneresponsefromnaiveTcellsdemonstratesitscriticalroleinregulationoftheimmuneresponseandstronglysuggestsitspotentialusefulnessincancertherapy.
Synonyms:Interleukin-12subunitp70,CLMF,NKSF
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.IL-12exertsavarietyofBIOLOGicaleffectsonTandnaturalkillercells.ApartfrompromotionofTh1developmentanditsABIlitytopromotecytolyticactivityitmediatessomeofitsphysiologicalactivitiesbyactingasapotentinducerofIFN-gammaproductionandthestimulationofothercytokinesfromperipheralbloodTandNKcells.IFN-gammathenenhancestheabilityofthephagocyticcellstoproduceIL-12andotherproinflammatorycytokines.Thus,IL-12inducedIFN-gammaactsinapositivefeedbackloopthatrepresentsanimportantamplifyingmechanismintheinflammatoryresponsetoinfections.
ItsroleindirectingdevelopmentofaTh1typeimmuneresponsefromnaiveTcellsdemonstratesitscriticalroleinregulationoftheimmuneresponseandstronglysuggestsitspotentialusefulnessincancertherapy.
Synonyms:Interleukin-12subunitp70,CLMF,NKSF
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