IBL/Eotaxin (mouse) ELISA/BE45261/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x1h,1x10min. |
| Standardrange | 31.3-2000pg/ml |
| Specimen/Volumes | 50µlserum,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Eotaxin(mouse)ELISA
EotaxinisamemberoftheCCchemokinefamilyofinflammatoryandimmunoregulatorycytokines.ConstitutiveEotaxinmRNAexpressionhasbeendetectedinmultipletissues,mostoftenitappearstobeinducedbyinflammatorycytokinessuchasIL-1,TNF-alphaandIFN-gammainfibroblasts,endothelialandepithelialcells.FollowingallergenchallengeEotaxinmRNAhasbeenshowntoberapidlyup-regulatedinairwayepitheliumanalveolarmacrophages.Eotaxinexpressionhasalsobeendetectedinsmoothmusclecells,chondrocytesandeosinophils.MouseEotaxinactivityismediatedbythemouseCCchemokinereceptorCCR3,which,unlikehumanCCR3,canalsobeactivatedbymouseMIP-1alpha.AmongCCchemokinefamiliymembers,EotaxinisfunctionallyandstructurallymostlyrelatedtotheMCP/Eotaxinproteins.MouseEotaxinCDNAencodesa97aminoacidresidueprecursorproteinthatiscleavedtogeneratethe74aaresiduematureprotein.MouseEotaxinhasbeenshowntobeapotentchemoattractantforeosinophilsduringinflammationandallergicreactionsandtobeinvolvedinthegrowthofmyeloidcellProgenitorsandthedifferentiationofmastcellsduringembryonicdevelopment.Aroleinnumerouseosinophil-associatedgastrointestinalsdisordersasfoodallergy,parasiticinfections,allergiccolitisandinflammatoryBoweldiseasehasbeendescribed.
Synonyms:Small-inducIBLecytokineA11,CCL11
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Synonyms:Small-inducIBLecytokineA11,CCL11
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