HMGB1中的IBL/BoxA，人类和；小鼠，无脂多糖-500µ；g/REHM013/
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Other_reagents
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商品介绍
| Type | recombinantprotein |
| AvailableSizes | 500µg |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:BoxAfromHMGB1,human&mouse,LPS-free-500µg
BoxAisoneofthehighlyconservedDNAbindingdomainsofHMGB1protein(HMGboxes).
BoxAisanantagoNISTforHMGB1bindingtoitsreceptorRAGE,andinhibitsHMGB1cytokineeffectsinvivo.TheBoxAweprovidehasnodifferencefromthesequenceofthehumanormouseHMGB1,andasaself-antigenelicitsverylowimmunologicalresponses.
BoxAprotectsagainstsepsisinamouseperitonitismodel(Yangetal.Reversingestablishedsepsiswithantagonistsofendogenoushigh-mobilitygroupbox1.ProcNatlAcadSciUSA2004,101:296-301),andfromhepatitisinamousemodelofHBVinfection(Sitiaetal.TreatmentwithHMGB1inhibitorsdiminishesCTL-inducedliverdiseaseinHBVtransgenicmice.JLeukocBiol2007,81:100-7).
DendriticcellspromotetheirownmaturationandTcellproliferation,survivalandTh1differentiationbysecretingHMGB1,andBoxAinhibitstheseactivities(Dumitriuetal.ReleaseofHMGB1bydendriticcellscontrolsTcellactivationviathereceptorforadvancedglycationendproducts(RAGE).JImmunol2005,174:7506-15).
BoxAalsoinhibitsthechemotacticactivityofHMGB1onendothelialcellsandfibroblasts,andthemitogenicactivityofHMGB1forstemcells(MEBianchi,unpublished).
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.BoxAisanantagoNISTforHMGB1bindingtoitsreceptorRAGE,andinhibitsHMGB1cytokineeffectsinvivo.TheBoxAweprovidehasnodifferencefromthesequenceofthehumanormouseHMGB1,andasaself-antigenelicitsverylowimmunologicalresponses.
BoxAprotectsagainstsepsisinamouseperitonitismodel(Yangetal.Reversingestablishedsepsiswithantagonistsofendogenoushigh-mobilitygroupbox1.ProcNatlAcadSciUSA2004,101:296-301),andfromhepatitisinamousemodelofHBVinfection(Sitiaetal.TreatmentwithHMGB1inhibitorsdiminishesCTL-inducedliverdiseaseinHBVtransgenicmice.JLeukocBiol2007,81:100-7).
DendriticcellspromotetheirownmaturationandTcellproliferation,survivalandTh1differentiationbysecretingHMGB1,andBoxAinhibitstheseactivities(Dumitriuetal.ReleaseofHMGB1bydendriticcellscontrolsTcellactivationviathereceptorforadvancedglycationendproducts(RAGE).JImmunol2005,174:7506-15).
BoxAalsoinhibitsthechemotacticactivityofHMGB1onendothelialcellsandfibroblasts,andthemitogenicactivityofHMGB1forstemcells(MEBianchi,unpublished).
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