IBL/抗HMGB1鸡IgY多克隆抗体/ST326052226/
商品编号：
ST326052226
品牌：
TECAN
市场价：
¥0.00
美元价：
0.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Quantity/Tests | 50µg |
| Species/Antigen | human,rabbit,bovine,mouse,rat,pig |
| Host | Chicken |
| Subclass/Clone | N/A |
| Type | Polyclonal |
| Purification | AffinityPurified |
| Label | N/A |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-HMGB1ChickenIgYPolyclonalAntibody
HMGB1andHMGB2arechromatin-associatednuclearproteinsthatplayanimportantroleintranscriptionandDNArecombination.HMGproteinscontainahighlyacidicC-terminaldomainaswellastwoevolutionarilyconservedhighmobilitygroup(HMG)boxmotifsastheirN-terminus.
HMGboxesarefoundinnumerousDNAbindingproteinsandtranscriptionfactorsandallowHMGproteinstobindandtobendDNA.Especially,HMGB1isknownasamphoterin,itmediatesneuriteoutgrowth,anditbindsreceptorsforadvancedglycationendproducts(RAGE).Recently,
HMGB1wasunexpectedlyidentifiedasacytokinethroughstudiesofendotoxemiaandsepsis.
Theantibodyrecognizeshuman,rabbit,bovine,pig,rat,andmouseHMGB1withoutthemHMGB2.Thespecificityoftheantibodywasconfirmedbywesternblotanalysis.Asyntheticpeptidecorrespondingtoaminoacids(KPDAAKKGVVKAEK)ofhumanHMGB1wasusedasanimmunogen.Theantibodywaspurifiedfromeggyolkbyaffinitychromatography.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.HMGboxesarefoundinnumerousDNAbindingproteinsandtranscriptionfactorsandallowHMGproteinstobindandtobendDNA.Especially,HMGB1isknownasamphoterin,itmediatesneuriteoutgrowth,anditbindsreceptorsforadvancedglycationendproducts(RAGE).Recently,
HMGB1wasunexpectedlyidentifiedasacytokinethroughstudiesofendotoxemiaandsepsis.
Theantibodyrecognizeshuman,rabbit,bovine,pig,rat,andmouseHMGB1withoutthemHMGB2.Thespecificityoftheantibodywasconfirmedbywesternblotanalysis.Asyntheticpeptidecorrespondingtoaminoacids(KPDAAKKGVVKAEK)ofhumanHMGB1wasusedasanimmunogen.Theantibodywaspurifiedfromeggyolkbyaffinitychromatography.
品牌介绍
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