IBL/淀粉样β（x-40）ELISA/RE59741/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x18h,1x1h,1x30min |
| Standardrange | 7.81-500pg/mL |
| Specimen/Volumes | 100µLserum,plasma,CSF,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Amyloid-beta(x-40)ELISA
PreviouslysoldasJP27713Amyloid-beta(1-40)ELISA.
ThisassaycanmeasureAβ(1-40)variantscleavedattheNterminalsidebyanycause.TheplaqueswhichappearinthebrainsofAlzheimer"sdiseasepatientsaremostlyconstitutedbytheAmyloidβprotein(Aβ).Aβisapeptidewhichconsistsof40or42(43)aminoacids,andreportsshowthatthisiscleavedfromβ-andγ-secretasefromtheamyloidprecursorprotein(APP).ReportshaveshownmanyvariantsofAβexistandareclarifiedintotheculturesupernatantfromtheAPPCDNAtransfectedmouseneuroblastomacell.FurThermore,in1995,adominantanddifferentialdepositionofdistinctβamyloidpeptidespecies,Aβ(N3pE),insenileplaqueswasfoundbySaidoetal.Thismodifiedmolecule,startingatthe3rdaminoterminalresidue,glutamate,wasdiscoveredtoconverttopyroglutamatethroughintramoleculardehydration.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.ThisassaycanmeasureAβ(1-40)variantscleavedattheNterminalsidebyanycause.TheplaqueswhichappearinthebrainsofAlzheimer"sdiseasepatientsaremostlyconstitutedbytheAmyloidβprotein(Aβ).Aβisapeptidewhichconsistsof40or42(43)aminoacids,andreportsshowthatthisiscleavedfromβ-andγ-secretasefromtheamyloidprecursorprotein(APP).ReportshaveshownmanyvariantsofAβexistandareclarifiedintotheculturesupernatantfromtheAPPCDNAtransfectedmouseneuroblastomacell.FurThermore,in1995,adominantanddifferentialdepositionofdistinctβamyloidpeptidespecies,Aβ(N3pE),insenileplaqueswasfoundbySaidoetal.Thismodifiedmolecule,startingatthe3rdaminoterminalresidue,glutamate,wasdiscoveredtoconverttopyroglutamatethroughintramoleculardehydration.
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