| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x1h,1x10min |
| Standardrange | 1.56-100pg/mL |
| Specimen/Volumes | 50µLserum,plasma,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | EU:CE |
Interleukin-6(IL-6)isamulti-functionalcytokinethatregulatesimmuneresponses,acutephasereactionsandhematopoiesisandmayplayacentralroleinhostdefensemechanisms.IL-6isusuallynotproducedconstitutivelybynormalcells,butitsexpressionisreADIlyinducedbyavarietyofcytokines,lipopolysaccharideorviralinfections.IL-6isapleiotropiccytokineproducedbyavarietyofcells.Itactsonawiderangeoftissues,exertinggrowth-induction,growth-inhibition,anddifferentiationrespectively,dependingonthenatureofthetargetcells.TheabnormalproductionofIL-6wasfirstsuggestedtoberelatedtopolyclonalB-cellactivationwithautoantibodyproductioninpatientswithcardiacmyxoma.Sincethen,IL-6hasbeensuggestedtobeinvolvedinthepathogenesisofavarietyofdiseases.MeasurementofIL-6levelsinserumandotherbodyfluidsthusprovidesmoredetailedinsightsintovariouspathologicalsituations.
Infections
Bodyfluidsofpatientswithacutelocalbacterialorviralinfectionsandserumofpatientswithgram-negativeorpositivebacteremiacontainelevatedlevelsofBIOLOGicallyactiveIL-6.ObstetricInfections
IL-6hasemergedasareportercytokineforintraamnioticinfection.Diseasesassociatedwithanalteredimmunesystem(polyclonalB-cellabnormalitiesorautoimmunediseases)
ElevatedlevelsofcirculatingIL-6havebeendetectedinpatientswithcardiacmyxoma,Castleman"sdisease,rheumatoidarthritis,IgMgammopathyandinthosewithacquiredimmunodeficiencysyndromeaswellasalcoholiclivercirrhosis.Proliferativediseases
ElevatedplasmalevelsofIL-6areobservedinpatientswithpsoriasisandmesangialproliferativeglomerulonephritis.NeoplasticDiseases
IncreasedsystemiclevelsofIL-6havebeendetectedinpatientswithmultiplemyeloma,otherB-celldyscrasias,Lennert"sTlymphoma,Castleman"sdisease,renalcellcarcinomaandvariousothersolidtumors.Inflammatoryresponses
IL-6isinvolvedintheinductionofacutephaseproteinsandinductionoffever.ElevatedserumlevelsofIL-6arealsofoundinpatientswithsevereburns,inserumandplasmaasaMarkerforpredictingpostoperativecomplications,inserumandurineofrecipientsofkidneytransplantsbeforerejection,intheserumofsepticshockpatientsandinpatientswithinflammatoryarthritisandtraumaticarthritis.Synonyms:B-cellstimulatoryfactor-2,BSF-2,Interferonbeta-2,Hybridomagrowthfactor,CTLdifferentiationfactor,CDF
