| Kitsize | 96 |
| Method | RIA(CT) |
| Incubationtime | 1x1hwithshaking |
| Standardrange | 0.35-14nmol/L |
| Specimen/Volumes | 50µLSerum |
| Substrate/isotope | 125I<111kBq |
| RegulatoryStatus: | EU:CE |
Radioimmunoassayfortheinvitroquantitativemeasurementofhuman3,5,3’Triiodothyronine(T3)inserum.
BIOLOGicalactivity
Thethyroidglandexertspowerfulandessentialregulatoryinfluencesongrowth,differentiation,cellularmetabolism,andgeneralhormonalbalance,aswellasonthemaintenanceofmetabolicactivityandthedevelopmentoftheskeletalandorgansystem.Thehormonesthyroxine(T4)and3,5,3’triiodothyronine(T3)circulateinthebloodsteam,mostlyboundtotheplasmaprotein,thyroxinebindingglobulin(TBG).TheconcentrationofT3ismuchlessthanthatofT4,butitsmetabolicpotencyismuchgreater.
Clinicalapplications
T3determinationisanimportantfactorinthediagnosisofthyroiddisease.ItsmeasurementhasuncoveredavariantofhyperthyroidisminthyrotoxicpatientwithelevatedT3levelsandnormalT4levels.AnincreaseinT3withoutanincreaseinT4isfrequentlyaforerunnerofrecurrentthyrotoxicosisinpreviouslytreatedpatients.Inotherpatients,euthyroidismisattributabletonormalT3,althoughtheirT4valuesaresubnormal.
T3determinationisalsousefulinmonitoringbothpatientundertreatmentforhyperthyroidismandpatientswhohavediscontinuedanti-thyroiddrugtherapy.Itisespeciallyvaluableindistinguishingbetweeneuthyroidsubjects.
Inwomen,T3levelsareelevatedduringpregnancy,duringestrogentreatment,andcontraceptivehormonetherapy.WhenT3levelsparallelTBGincreasesinamanneranalogoustoT4levels,thesechangesarenotareflectionofalteredthyroidstatus.
DistributedbyIBLInternational
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