IBL/ANP心钠素RIA/ED29011/
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商品介绍
| Kitsize | 100 |
| Method | RIA |
| Incubationtime | 2x18h,2x30min |
| Standardrange | 7.8-1000pg/mL |
| Specimen/Volumes | 500µLplasma/extraction |
| Substrate/isotope | 125I<37kBq |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:ANPAtrialNatriureticPeptidRIA
Mammalianatriacontainspecificgranules,whichresemblesecretorygranulesinendocrinecells(1,2).DeBoldetal.(3)showedthatthenumberoftheseatrialgranuleswasinverselycorrelatedtothevolumeoftheextracellularfluid.Fromatrialextracts,peptideshavebeenisolated,sequenced,andsynthesized(4-10).Inhumanatria,threepeptidesseemtobeimportant:a28-aminoacidscomponent(alfaANP),andabiosyntheticprecursor(gamma-ANP,126aminoacids).BIOLOGicalactivitywashighestforalfa-ANP(11).Invitroandanimalexperimentshaveshownthatalfa-ANPmaypossesseimportantbiologicalactions:ithasdiureticandnatriureticactivities,relaxessmoothmuscle,itssecretionisstimulatedbyvolumeloADIng,anditopposesthealdosteronesecretion(reviewedin12-17).Theseeffectsarethoughttobemediatedbyalfa-ANPcirculatinginperipheralblood.Measurementsofthispeptideinhumanplasma(18-30)couldbeofvalueindeterminingtheroleofANPintheendocrinesystemandinvariouspathophysiologicalstatesinman(31-34).Thiskitdecribesasimple,sensitiveandreliableradioimmunoassayforANPinhumanplasma
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.品牌介绍
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