IBL/酰化Ghrelin（人）384孔ELISA/CMA05106-384/
商品编号：
CMA05106-384
品牌：
TECAN
市场价：
¥0.00
美元价：
0.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 384determinations |
| Method | ELISA |
| Incubationtime | 1x3hatRT;1xatRT |
| Standardrange | 2-250pg/mL |
| Specimen/Volumes | 25µL |
| Substrate/isotope | ER405-414nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:AcylatedGhrelin(human)384wellELISA
ThisassayhasbeendevelopedtoscreenGOATactivitybymonitoringAcylatedGhrelinproductionincellculturemedia.Ghrelindiscoveredin1999,isfastbecominganendocrinologytargetofthemillennium.Ghrelin,identifiedinratstomachasanendogenousligandfortheGHsecretagoguereceptor,ismainlyproducedinstomach,buthasbeendemonstratedinmanyotherorgans.InadditiontoGH-releasingpropertiesanditsorexantaction,Ghrelincouldactasanhormonehavingeffectsongastricmotility(similaritywiththepeptidehormonemotilin),acidicsecretion,cardiovascularaction,antiproliferativeeffects,pancreaticandglucosemetabolismfunction,sleep...GhrelingeneraisestomRNAprepro-ghrelinof117aminoacids.ThisprecursorisprocessedintoGhrelin,28aminoacids(human).Beforebeingsecreted,thispeptideisoctanoylatedatSer3byGOAT(GhrelinOctanoylAcylTransferase).ThisstepisessentialforBIOLOGicalactivitymakingGOATaperfecttargetfordrugsinfeedingbehaviour.Interestingly,thepotentialtherapeuticimportanceofthishormoneisnotrestrictedtoregulationoffoodintakebutalsoincachexia(relatedtocancertreatment,anorexianervosaorischemia)gastricmotilityandmaybeinvolvedinosteoporosis,somatopause,infertilityandovulationinduction,neurologicaldisorders(Alcoholism,PostTraumaticStressdisorders...)andcardiovasculardiseases.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.品牌介绍
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