Theguthormoneglucagon-likepeptide-1(GLP-1)issecretedinresponsetonutrientintakeandplaysanessentialroleintheregulationofglucosehomeostasis.TherearemultipleformsofGLP-1,amongwhichGLP-1(7-37)andGLP-1(7-36)NH2areconsideredtobeBIOLOGicallyactive.AccuratemeasurementofbothformsofactiveGLP-1isnotonlyimportantforunderstandingthephysiologicalmechanismsofbloodglucoseregulationinhealthypeopleandtype2diabetespatients,butitisalsoofutmostimportanceforbothclinicalandpreclinicalstudiesofGLP-1agoNISTsandDPP4inhibitors(e.g.Sitagliptin®,Saxagliptin®).

AmongthecurrentlyavailablemethodsformeasuringactiveGLP-1peptides,immunoassaysaregreatlyfavoredbecauseoftheirsensitivity.However,mostimmunoassaysstillrequireanextractionstepofactiveGLP-1whichistediousandtime-consuming.

Tomeettheseneeds,areliableanduser-friendlyassaywithahighsensitivityisessentialduetolowplasmalevelsoftheactiveformGLP-1.

Advantagesofourassay

• Sensitivity:0.10(pmol/L)
• Specificity:
  GLP-1(7-36)NH2:100%
  GLP-1(7-37):100%
  Others< 0.32%
• Assaytime:2.5hours
• Noextractionneeded

GLP-1activeformsELISAwithoutextraction

IBLInternationalishappytopresenttheGLP-1activeformsELISAwithoutextractionforthereliablemeasurementofbiologicallyactiveformsofGLP-1.

OurassayneedsnoextractionstepanddetectsbothformsoftheactiveGLP-1withhighsensitivity.

^{*distributedbyIBLInternational}ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.