IBL/FGF21 ELISA/JP27997/
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美元价：
0.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x18h,2x30min. |
| Standardrange | 31.3-2000pg/mL |
| Specimen/Volumes | 100µLserum,EDTAplasma,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:FGF21ELISA
TheFGF19subfamilycomposedofFGF15/19,FGF21andFGF23bindstheFGFreceptorsco-joinedbyα-orβ-Klothoanditischaracterizedasafactorgroupwhichhashormonalfunctions.Thenovelsystemconsistedofα/βKlothoandFGF19subfamilyregulatesintegrallymetabolismofminerals,lipids,energyandaminoacids.Thisnovelregulatingsysteminvolvesimportanthomeostaticmechanismsinthebodysuchasbileacidandcholesterolmetabolismintheliver(throughFGF19),energyandglycolipidsmetabolism(throughFGF21)andphosphate,calciumandvitaminDmetabolisminkidney(throughFGF23)infastingstate.
FGF21issecretedintheliveranditisresponsIBLeforglucoseuptakeofADIpocytes.FGF21bindstoareceptorunitconsistingofFGFRandβ-Klotho.IthasbeenshownthattreatinganimalswithFGF21leadstoincreasedenergyexpenditure,fatutilizationandlipidexcretionmeaningadecreaseofglucoseandtriglyceridelevelsinblood.
FGF21levelsinbloodcorrelatewithmanydiseaseslikegestationaldiabetesmellitus,mitochondrialdysfunctioninHIVinfection,friedreichataxia,coronaryarterydisease,carotidatherosclerosis,non-alcoholicfattyliverdisease,rheumatoidarthritis,diabeticnephropathy,type2diabetes,dyslipidemia,obesityandmetabolicsyndrome.
ThiskitmeasuresFGF21levelsinserum,EDTAplasmaandcellculturesupernatants.
Separatecontrolsetavailableonrequest
DistributedbyIBLInternational
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.FGF21issecretedintheliveranditisresponsIBLeforglucoseuptakeofADIpocytes.FGF21bindstoareceptorunitconsistingofFGFRandβ-Klotho.IthasbeenshownthattreatinganimalswithFGF21leadstoincreasedenergyexpenditure,fatutilizationandlipidexcretionmeaningadecreaseofglucoseandtriglyceridelevelsinblood.
FGF21levelsinbloodcorrelatewithmanydiseaseslikegestationaldiabetesmellitus,mitochondrialdysfunctioninHIVinfection,friedreichataxia,coronaryarterydisease,carotidatherosclerosis,non-alcoholicfattyliverdisease,rheumatoidarthritis,diabeticnephropathy,type2diabetes,dyslipidemia,obesityandmetabolicsyndrome.
ThiskitmeasuresFGF21levelsinserum,EDTAplasmaandcellculturesupernatants.
Separatecontrolsetavailableonrequest
DistributedbyIBLInternational
品牌介绍
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