IBL/11去氧皮质醇RIA（CT）/MG11111/
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商品介绍
| Kitsize | 96 |
| Method | RIACT |
| Incubationtime | 2,5h37°C |
| Standardrange | 0,3-65ng/mL |
| Specimen/Volumes | 25µLSerum |
| Substrate/isotope | 125I<105kBq |
| RegulatoryStatus: | EU:CE |
Detailsfor:11-DesoxycortisolRIA(CT)
RADIoimmunoassayfortheinvitroquantitativemeasurementof11-Desoxycortisolinhumanserum.
11-Desoxycortisol(CompoundS)isanintermediatesteroidintheglucocorticoidsbiosynthesis.Precusorofthecortisol,itcomesfrom17-hyroxyprogesteroneafteractionofthe11betahydroxylase.Thisparameterisinterestingforthediagnosisandfollowupoftreatmentincaseofsurrenalenzymaticdeficiencyin11betahydroxylasewhichisresponsIBLeforcongenitalsurrenalhyperplasiainchildrenandhyperandrogenicsinadultwomen.
Underhypothalamic-pituitarycontrolviatheAdrenocorticotropichormone(ACTH),thesecretionof11-Desoxycortisolfollowsanycthemeralvariation:itreachesamaximuminthemorning(around8a.m.)andaminimalduringthenight(between0to4a.m.).
Themeasureofthe11-Desoxycortisolcanbeperformedinserumusingimmunologicalcompetitionmethods(RIA).
Themetopyroneinhibitsthe11betahydroxylaseandtheconversionofthe11-Desoxycortisolincortisol.
ThemetopyronetestisanindicatoroftheACTHreserve.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.11-Desoxycortisol(CompoundS)isanintermediatesteroidintheglucocorticoidsbiosynthesis.Precusorofthecortisol,itcomesfrom17-hyroxyprogesteroneafteractionofthe11betahydroxylase.Thisparameterisinterestingforthediagnosisandfollowupoftreatmentincaseofsurrenalenzymaticdeficiencyin11betahydroxylasewhichisresponsIBLeforcongenitalsurrenalhyperplasiainchildrenandhyperandrogenicsinadultwomen.
Underhypothalamic-pituitarycontrolviatheAdrenocorticotropichormone(ACTH),thesecretionof11-Desoxycortisolfollowsanycthemeralvariation:itreachesamaximuminthemorning(around8a.m.)andaminimalduringthenight(between0to4a.m.).
Themeasureofthe11-Desoxycortisolcanbeperformedinserumusingimmunologicalcompetitionmethods(RIA).
Themetopyroneinhibitsthe11betahydroxylaseandtheconversionofthe11-Desoxycortisolincortisol.
ThemetopyronetestisanindicatoroftheACTHreserve.
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