IBL/反向T3（rT3）ELISA/30123153/
市场价：
¥6700.00
美元价：
4020.00
产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x1h(37°C),1x30min(37°C),1x15min(37°C) |
| Standardrange | 0.02–2ng/mL |
| Specimen/Volumes | 25µLSerum,EDTAPlasma |
| Substrate/isotope | TMB,450nm |
| RegulatoryStatus: | EU:CE |
Detailsfor:ReverseT3(rT3)ELISA
ForthedirectquantitativedeterminationofReverseTriiodothyronine(rT3)inhumanserumandplasmabyanenzymeimmunoassay.
3,3’,5’-Triiodo-L-thyroninealsoknownasreversetriiodothyronineorreverseT3(rT3),differsfrom3,3’,5’-Triiodo-L-thyronine(T3)inthepositionsoftheiodineatomsinthemolecule.ThemajorityofcirculatoryrT3issynthesizedbyperipheraldeiodinationofthyroxine(T4).BothT3andrT3bindtothyroidhormonereceptors,butincontrasttoT3,rT3hasnotbeenfoundyettostimulatereceptormetabolicactivity;itblocksreceptorsitesfromT3activation.TheratioofrT3toT3isavaluablebioMarkerofthemetabolismandfunctionofthyroidhormonesbecausetheprocessof5’monodeiodinationthatconvertsT4toT3andrT3to3,3’-T2isinhibitedinanumberofnon-thyroidalconditionssuchasfasting,anorexianervosa,malnutrition,diabetesmellitus,stress,severetraumaorinfection,hemorrhagicshock,hepaticdysfunction,pulmonarydiseasesandothers.Thisscenarioisknownas"Sickeuthyroid"syndromeor“LowT3”syndrome.
AnelevatedratioofrT3overT3isthereforeindicativeof"sickeuthyroid"syndromeandhelpstoexcludeadiagnosisofhypothyroidism,particularlyincriticallyillpatients1-9.
TheconcentrationofrT3couldbehighinpatientsonthefollowingmedications:amiodarone,dexamethasone,propylthiouracil,ipodate,propranolol,andtheanesthetichalothane.TheconcentrationofrT3couldbelowinpatientsonDilantin,whichdecreasesrT3duetoitsdisplacementfromthyroxine-bindingglobulinandtherefore
generatesanexcessiveclearanceofrT3.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.3,3’,5’-Triiodo-L-thyroninealsoknownasreversetriiodothyronineorreverseT3(rT3),differsfrom3,3’,5’-Triiodo-L-thyronine(T3)inthepositionsoftheiodineatomsinthemolecule.ThemajorityofcirculatoryrT3issynthesizedbyperipheraldeiodinationofthyroxine(T4).BothT3andrT3bindtothyroidhormonereceptors,butincontrasttoT3,rT3hasnotbeenfoundyettostimulatereceptormetabolicactivity;itblocksreceptorsitesfromT3activation.TheratioofrT3toT3isavaluablebioMarkerofthemetabolismandfunctionofthyroidhormonesbecausetheprocessof5’monodeiodinationthatconvertsT4toT3andrT3to3,3’-T2isinhibitedinanumberofnon-thyroidalconditionssuchasfasting,anorexianervosa,malnutrition,diabetesmellitus,stress,severetraumaorinfection,hemorrhagicshock,hepaticdysfunction,pulmonarydiseasesandothers.Thisscenarioisknownas"Sickeuthyroid"syndromeor“LowT3”syndrome.
AnelevatedratioofrT3overT3isthereforeindicativeof"sickeuthyroid"syndromeandhelpstoexcludeadiagnosisofhypothyroidism,particularlyincriticallyillpatients1-9.
TheconcentrationofrT3couldbehighinpatientsonthefollowingmedications:amiodarone,dexamethasone,propylthiouracil,ipodate,propranolol,andtheanesthetichalothane.TheconcentrationofrT3couldbelowinpatientsonDilantin,whichdecreasesrT3duetoitsdisplacementfromthyroxine-bindingglobulinandtherefore
generatesanexcessiveclearanceofrT3.
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