IBL/PSA，总ELISA/RE54091/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x5min,1x1h,1x20min |
| Standardrange | 1.5-25ng/mL |
| Specimen/Volumes | 25µLserum |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | EU:CE |
Detailsfor:PSA,totalELISA
Prostatecanceristhemostfrequenttypeofcancerfoundinmanandisthesecondcauseofdeathduetocancerinmales.Untilrecently,digitalrectalexamination(DRE)wasfrequentlyusedasonlydiagnosticmodalityforthedetectionofearlystagesofprostatecancer.IntherecentyearsthedeterminationofserumPSAlevelshasbecomethemostacceptedmethodtoimprovethediagnosticspecificityofDRE.AlthoughPSAisatissuespecificproteinandisnotsolelytumorspecific,ithasbecomethemostimportantMarkerforprostatecarcinoma,showingabetterspecificitythanotherbiochemicalmarkersusedinthiscontext(PAP,totalalkalinephosphatase,carcinoembryonicantigen,etc.)In1979,WangetalisolatedaspecificantigenfornormalprostatetissueandcalledthisproteinPSA.Asdemonstratedbyimmunohistologicalstudies,PSAislocalizedinthecytoplasmofprostateacinarcells,ductalepitheliumandinthesecretionontheductallumina,presentinnormal,benignhyperplasticandmalignantprostatetissuesaswellmetastaticprostatecancerandinseminalplasma.Ifthestructuralintegrityoftheprostateisdisturbedand/ortheglandsizeisincreased,theamountofPSAinthebloodplasmamaybecomeelevated.AnelevationofPSAlevelstovalueshigherthan3-4ng/mLhasbeenreportedforpatientswitheitherbenignprostatichypertrophy(BPH)orprostatecarcinoma.Atthisthresholdfollow-upexaminationsthatallowdifferentiatingbetweenthesetwoconditionsarerecommended.ThedeterminationofPSAserumlevelsisnotonlyimportantforthescreeningofpatientsforprostatecancer,butalsoformonitoringpatientsthathavebeentreatedforthisdisease.HereregularPSAmeasurementsareanimportanttooltoexaminethepotentialandactualeffectivenessofsurgeryorothertherapies.AnincreaseofPSAinpatientsafterrADIcalprostatectomyorradiotherapymayallowanearlierdiscoveryofresidualorrecurrentcarcinoma
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